Clinical trial · Interventional
Ispinesib In Combination With Capecitabine In Patients With Solid Tumors
A Phase I, Open-Label, Dose-Escalation Study of the Safety and Tolerability of Ispinesib in Combination With Capecitabine on an Every 21-Day Schedule in Subjects With Advanced Solid Tumors
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to determine the dose regimen of Ispinesib in combination with capecitabine in patients with solid tumors. Ispinesib is dosed by 1-hour intravenous infusion every 3 weeks and capecitabine is dosed orally, twice a day for 14 days with a 1 week rest period. A patient may continue to receive treatment as long as they are benefiting from the treatment. Blood samples will be taken at specific times to measure the amount of both drugs in your body at specific times after the drug is given. Blood samples will also be taken for lab tests such as complete blood counts and clinical chemistries. Physical exams will be performed before each treatment with Ispinesib. During the treatment phase, the patients will undergo regular assessments for safety and clinical response.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Solid Tumor Cancer | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Capecitabine | Drug | Capecitabine | ALIAS |
| Ispinesib | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Plasma levels for SB-715992 and Capecitabine
- timeFrame
- will be checked at Day 1 for Cycle 1.
Secondary outcomes (3)
- measure
- - Medical history
- timeFrame
- at screening
- measure
- - ECOG Performance Status, Physical Exam, vitals, & labs
- timeFrame
- done at screening, Week 1 (each cycle), & follow-up (f/u)
- measure
- - Continuous Adverse Event monitoring
- timeFrame
- throughout the study
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion criteria: * Histologically or cytologically confirmed diagnosis of an advanced solid tumor malignancy that is not responsive to standard therapies or for which there is no standard therapy. * ECOG (Eastern Cooperative Oncology Group) Performance Status of 0-2. * Bone marrow function: - ANC greater than 1500/mm3. * Platelet count greater than or equal to 100,000/mm3. * Hemoglobin greater than 9 g/dL. * Renal function: - Calculated creatinine clearance greater than or equal to 50 mL.min. * Total bilirubin greater than 1.5 mg/dL. * AST/ALT less than 2.5 X upper limit of normal. Exclusion criteria: * Females who are pregnant or nursing. * Pre-existing hemolytic anemia. * Pre-existing peripheral neuropathy greater than or equal grade 2. * Known deficiency in dihydropyrimidine dehydrogenase (DSD).
References
Publications (0)
Data not yet available