Cisplatin, Irinotecan, and Bevacizumab, in Treating Patients With Small Cell Lung Cancer

Inclusion Criteria:

* All patients must have histologically or cytologically documented small cell carcinoma of the bronchus
* The extensive disease classification for this protocol includes all patients with disease sites not defined as limited stage; limited stage disease category includes patients with disease restricted to one hemithorax with regional lymph node metastases, including hilar, ipsilateral and contralateral mediastinal, and/or ipsilateral supraclavicular nodes; extensive stage patients are defined as those patients with extrathoracic metastases, malignant pleural effusion, bilateral or contralateral supraclavicular adenopathy or contralateral hilar adenopathy
* Measurable or Non-measurable Disease
* No prior chemotherapy or investigational therapy for SCLC
* Radiation therapy must have been completed at least three weeks before initiation of protocol therapy
* No major surgical procedure within 28 days prior to starting treatment and fully recovered
* No minor surgical procedure (mediastinoscopy or core biopsy) within 7 days prior to starting treatment
* ECOG performance status: 0-2
* No "currently active" second malignancy other than non-melanoma skin cancers
* No CNS metastases; patients with a history of CNS metastases will NOT be eligible even if they have completed a course of CNS radiotherapy; all patients will have a screening brain CT or MRI to rule out occult CNS metastases
* No recent history of CVA (within 6 months)
* No serious or non-healing wound ulcer or bone fracture
* Patients with a history of significant bleeding episodes (e.g., hemoptysis, bleeding diathesis, upper or lower GI bleeding) are not eligible; patients with trace blood in the sputum ("blood tinged sputum") are eligible
* No myocardial infarction or significant change in anginal pattern within one year or current congestive heart failure (NYHA Class 2 or higher)
* Patients with a history of hypertension must be well controlled (\< 150/90) on a stable regimen of anti-hypertensive therapy
* No HIV-positive patients receiving combination anti-retroviral therapy because of possible pharmacokinetic interactions with the protocol treatment; (patients with immune deficiency are at an increased risk of lethal infections when treated with marrow-suppressive therapy)
* No chronic daily treatment with aspirin (\> 325 mg/day) or on non-steroidal antiinflammatory agents known to inhibit platelet function; no treatment with dipyridamole (Persantine), ticlopidine (Ticlid), clopidogrel (Plavix), cilostazol (Pletal), or other antiplatelet agents
* No clinically significant peripheral neuropathy (grade \>= 2)
* No known hypersensitivity to Chinese hamster ovary cell products or other recombinant human antibodies
* No treatment with therapeutic anticoagulation; prophylactic anticoagulation for central venous access devices is allowed provided requirements of INR \< 1.5 and PTT \< 1.2 x ULN are met; caution should be taken in treating patients with low dose heparin or low molecular weight heparin for DVT prophylaxis as there may be an increased bleeding risk with bevacizumab
* No current and/or recent (within 1 month) use of a thrombolytic agent; low dose thrombolytic therapy for maintenance of central venous catheter is allowed
* No clinically significant peripheral arterial disease
* Non-pregnant and non-nursing; the effect of the combination of bevacizumab, cisplatin, and irinotecan on the fetus and infant is unknown
* Granulocytes \>= 1,500/μl
* Platelets \>= 100,000/μl
* Serum Creatinine =\< ULN
* Total Bilirubin \< 2.0 mg/dl
* SGOT \< 2 x ULN
* INR \< 1.5
* PTT \< 1.2 x ULN
* Urine protein (dipstick) \< 1+