Clinical trial · Interventional
Radiologic Evaluation and Breast Density (READ)
A Population-Based Randomized Trial to Assess the Effects of Short-Term Cessation of Hormone Replacement Therapy (HRT) on Mammography Assessments and Breast Density
NCT00117663CI-TRIAL-00075730completedN/AResults postedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to determine whether cessation of hormone replacement therapy for one or two months before a screening mammogram will improve its performance by decreasing breast density.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| temporary discontinuation of hormone therapy for 1 month | Other | — | UNRESOLVED |
| temporary discontinuation of hormone therapy for 2 months | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- NO_INTERVENTION
- label
- No Hormone Suspension
- description
- No hormone suspension prior to screening mammogram
- type
- ACTIVE_COMPARATOR
- label
- 1 month hormone suspension
- description
- discontinuation of hormone therapy for 1 month prior to screening mammogram.
- interventionNames
- Other: temporary discontinuation of hormone therapy for 1 month
- type
- ACTIVE_COMPARATOR
- label
- 2 month hormone suspension
- description
- discontinuation of hormone therapy for 2 months prior to screening mammogram.
- interventionNames
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 45 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * 1 or more prior screening mammograms at Group Health Cooperative within the past 2 years * Currently taking HRT * Taking HRT at prior screening mammogram * Due for a screening mammogram Exclusion Criteria: * BI-RADS breast density of 1 (entirely fat) * Previous cardiovascular events (heart surgery, catheterization, stent bypass, angioplasty, stroke, DVT) * Previous breast cancer * History of breast implants * Breast reduction since last mammogram * Mastectomy * History of using Tamoxifen or Raloxifene * Declined contact or use of data for research
References
Publications (4)
- DERIVEDLowry SJ, Aiello Bowles EJ, Anderson ML, Buist DS. Predictors of breast density change after hormone therapy cessation: results from a randomized trial. Cancer Epidemiol Biomarkers Prev. 2011 Oct;20(10):2309-12. doi: 10.1158/1055-9965.EPI-11-0629. Epub 2011 Aug 3. PMID 21813728
- DERIVEDNewton KM, Anderson ML, Reed SD, Bowles EJ, Buist DS. Factors associated with non-compliance with hormone therapy cessation before screening mammography. Climacteric. 2011 Apr;14(2):268-74. doi: 10.3109/13697137.2010.520172. Epub 2010 Oct 27. PMID 20979462
- DERIVEDAiello Bowles EJ, Anderson ML, Reed SD, Newton KM, Fitzgibbons ED, Seger D, Buist DS. Mammographic breast density and tolerance for short-term postmenopausal hormone therapy suspension. J Womens Health (Larchmt). 2010 Aug;19(8):1467-74. doi: 10.1089/jwh.2009.1681. PMID 20575711
- DERIVEDReed SD, Buist DS, Anderson ML, Bowles EJ, Fitzgibbons D, Seger D, Newton KM. Short-term (1-2 mo) hormone therapy cessation before mammography. Menopause. 2009 Nov-Dec;16(6):1125-31. doi: 10.1097/gme.0b013e3181a5ce60. PMID 19455069