Picoplatin as Second-Line Therapy for Patients With Small Cell Lung Cancer

This is a Phase II research study that is designed for patients who have small cell lung cancer (SCLC) that is no longer responding to treatment. Patients will receive picoplatin, a new platinum-based agent that is currently under investigation, in 21-day cycles.

Sex

All

Minimum age

18 Years

Main inclusion criteria:

1. Diagnosis of small cell lung cancer.
2. Patients must have had one prior chemotherapy regimen which must have included either cisplatin or carboplatin.

\[Additional eligibility criteria apply.\]

Exclusion Criteria:

* Prior radiotherapy that included \> 30% of the bone marrow (i.e., the whole of the pelvis or half of the spine).
* Significant chronic or recent acute gastrointestinal disorder with diarrhea as a major symptom.
* Significant heart disease.
* Uncontrolled, untreated, unstable, or symptomatic brain tumors or central nervous system disease.
* Grade 2+ peripheral neuropathy (a condition caused by damage to the nerves in the peripheral nervous system).

\[Additional exclusion criteria apply.\]

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