Clinical trial · Interventional
Effects of Aerobic Exercise Versus Weight Training in Breast Cancer Survivors During Chemotherapy
Comparison of Aerobic Versus Resistance Exercise Training in Enhancing Quality of Life in Early Stage Breast Cancer Survivors Receiving Chemotherapy: A Multi-Centre Randomized Trial
NCT00115713CI-TRIAL-00082252completedPhase 3ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to compare the effects of two different types of exercise, aerobic exercise training (AET) and resistance exercise training (RET), on quality of life (QoL) in early stage breast cancer survivors receiving chemotherapy. It is hypothesized that both AET and RET would have beneficial effects on QoL.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Neoplasms | Breast Neoplasm | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Aerobic Exercise Training | Behavioral | — | UNRESOLVED |
| Resistance Exercise Training | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Quality of Life
Secondary outcomes (6)
- measure
- Physical Fitness
- measure
- Body Composition
- measure
- Lymphedema
- measure
- Treatment Completion Rates
- measure
- Selected Biomarkers
- measure
- Exercise Adherence Rates and Determinants
Eligibility
Eligibility (as posted)
- Sex
- Female
Show eligibility criteria text
Inclusion Criteria: * Breast cancer early stage I -IIIA * Completed axillary surgery * Scheduled to receive adjuvant chemotherapy for 9 - 24 weeks * Approval of the treating oncologist * Able to understand and provide written informed consent in English or French (Ottawa) * 18+ years of age * No uncontrolled hypertension, cardiac illness, psychiatric condition * No contraindication to exercise as determined by a fitness test Exclusion Criteria: * Pregnant. * Unwilling to accept randomization. * Any medical condition that would be a contraindication to exercise. The clinicians will make this decision. * Unwilling to travel to/participate in the exercise program as defined by the protocol. * Previous chemotherapy (previous cancer is NOT an exclusion criteria). * Cancer recurrence. * Planned/known absence of greater than 2 weeks during the intended study period. * Previous therapy for known breast cancer. * Those who have had TRAM (i.e., Transabdominal Rectus Abdominus Muscle Reconstructive Surgery) done. * Moderate lymphedema (\>20% or \>200mL difference between the affected arm and the unaffected arm).
References
Publications (4)
- DERIVEDAn KY, Arthuso FZ, Kang DW, Morielli AR, Ntoukas SM, Friedenreich CM, McKenzie DC, Gelmon K, Mackey JR, Courneya KS. Exercise and health-related fitness predictors of chemotherapy completion in breast cancer patients: pooled analysis of two multicenter trials. Breast Cancer Res Treat. 2021 Jul;188(2):399-407. doi: 10.1007/s10549-021-06205-8. Epub 2021 Mar 29. PMID 33779887
- DERIVEDCourneya KS, Segal RJ, McKenzie DC, Dong H, Gelmon K, Friedenreich CM, Yasui Y, Reid RD, Crawford JJ, Mackey JR. Effects of exercise during adjuvant chemotherapy on breast cancer outcomes. Med Sci Sports Exerc. 2014 Sep;46(9):1744-51. doi: 10.1249/MSS.0000000000000297. PMID 24633595
- DERIVEDDolan LB, Gelmon K, Courneya KS, Mackey JR, Segal RJ, Lane K, Reid RD, McKenzie DC. Hemoglobin and aerobic fitness changes with supervised exercise training in breast cancer patients receiving chemotherapy. Cancer Epidemiol Biomarkers Prev. 2010 Nov;19(11):2826-32. doi: 10.1158/1055-9965.EPI-10-0521. Epub 2010 Sep 22. PMID 20861399
- DERIVEDCourneya KS, Reid RD, Friedenreich CM, Gelmon K, Proulx C, Vallance JK, McKenzie DC, Segal RJ. Understanding breast cancer patients' preference for two types of exercise training during chemotherapy in an unblinded randomized controlled trial. Int J Behav Nutr Phys Act. 2008 Oct 27;5:52. doi: 10.1186/1479-5868-5-52. PMID 18954442