131-I-TM-601 Study in Adults With Recurrent High-Grade Glioma

Inclusion Criteria:

* Patient must have a histologically confirmed unilateral, supratentorial malignant glioma (grade 3 or 4, anaplastic astrocytoma, gliosarcoma, glioblastoma multiforme or malignant oligoastrocytoma)
* Patient must have glioma progression or recurrence following radiotherapy that was no less than 50 Gy (+/- chemotherapy; +/- surgery)
* Patient must be a candidate for resection of the recurrent tumor (surgical requirements are detailed in the study protocol)
* Imaging must show recurrent, unilateral, supratentorial tumor(s)
* There is no diffuse leptomeningeal disease
* For patients with previous radiosurgery or enhanced radiotherapy, based on neurosurgeon's judgment, the area of enhancement can be removed during the surgery
* Patient must have recovered from toxicity of prior therapy
* Patient must be \> 18 years of age.
* Patient has a Karnofsky Performance Status greater than or equal to 60%
* Patient must have a life expectancy of at least 3 months
* Patient has no uncontrolled seizures or other neurological conditions which would interfere with evaluation
* Patient is not currently receiving, or is not anticipated to receive, concomitant anticancer agent(s) during the course of this study
* Patient must have given informed consent

Exclusion Criteria:

* Patient with concurrent malignancy (except curatively treated basal or squamous cell carcinoma of the skin or carcinoma in situ of cervix and/or breast) or patients with prior malignancies that have not been disease-free for five years
* Patient has presence of non-contiguous satellite lesions
* Patient with known allergy to iodine, iodine containing drugs or contrast agent
* Patient with the potential for pregnancy or impregnating their partner and who do not agree to follow an acceptable birth control method to avoid conception
* Pregnant or breast feeding females
* Patient is not maintained on a stable corticosteroid regimen
* New onset of conditions not present prior to surgery (as detailed in Study Protocol) which would make patient an inappropriate study candidate, or as determined by Investigator