BMS-354825 or Imatinib Mesylate in Treating Patients With Chronic Phase Chronic Myelogenous Leukemia That Did Not Respond to Previous Imatinib Mesylate

DISEASE CHARACTERISTICS:

* Diagnosis of chronic phase chronic myelogenous leukemia (CML), meeting all of the following criteria:

  * Less than 15% blasts in peripheral blood and bone marrow
  * Less than 20% basophils in peripheral blood
  * Less than 30% blasts and promyelocytes in peripheral blood and bone marrow
  * Platelet count ≥ 100,000/mm\^3 (unless thrombocytopenia is due to recent therapy)
  * No extramedullary involvement (other than liver or spleen)
* Philadelphia chromosome (Ph)-positive disease by cytogenetic analysis
* Must have developed resistant disease during prior treatment with imatinib mesylate\* at a dose of 400-600 mg/day\*\*, as defined by 1 of the following:

  * Loss of major cytogenetic response (MCyR)

    * Achieved a confirmed MCyR and subsequently no longer meets the MCyR criteria
    * Documented increase in Ph-positive metaphases by 30% on 2 cytogenetic analyses performed ≥ 4 weeks apart during treatment with imatinib mesylate
  * Loss of complete hematologic response (CHR)

    * Achieved a confirmed CHR and subsequently no longer meets the CHR criteria on all asessments over a consecutive 2-week period during treatment with imatinib mesylate
  * Continuously increasing WBC count on ≥ 2 consecutive evaluations ≥ 2 weeks apart with the final assessment showing a doubling of WBC from the nadir to ≥ 20,000/mm\^3 OR an absolute increase in WBC by \> 50,000/mm\^3 above the lowest count after starting imatinib mesylate
  * No CHR after 3 months of treatment with imatinib mesylate at a dose of 400-600 mg/day
  * No cytogenetic response after 6 months of treatment with imatinib mesylate at a dose of 400-600 mg/day
  * No MCyR after 12 months of treatment with imatinib mesylate at a dose of 400-600 mg/day NOTE: \*Imatinib mesylate does not need to be the most recent treatment for CML

NOTE: \*\*Imatinib mesylate dose ≤ 600 mg/day

* Able to tolerate chronic administration of imatinib mesylate at the highest dose received during prior treatment

  * No imatinib mesylate-related non-hematologic toxicity ≥ grade 3
  * No grade 4 imatinib mesylate-related hematologic toxicity lasting more than 7 days
  * No imatinib mesylate-related toxicity that led to discontinuation or disruption of dosing for \> 4 weeks
* No previously identified BCR-ABL mutation of 1 of the following types:

  * L248V
  * G250E
  * Q252H/R
  * Y253H/F
  * E255K/V
  * T315I/D
  * F317L
  * H369P/R
* No prior diagnosis of accelerated phase or blast crisis CML

  * Patients who previously met the criteria for accelerated phase or blast crisis CML who achieved CHR during treatment with imatinib mesylate and then subsequently progressed to chronic phase CML are not eligible
* Ineligible for or unwilling to undergo hematopoietic stem cell transplantation

PATIENT CHARACTERISTICS:

Age

* 18 and over

Performance status

* ECOG 0-1

Life expectancy

* At least 3 months

Hematopoietic

* See Disease Characteristics
* No history of a significant bleeding disorder unrelated to CML, including any of the following:

  * Congenital bleeding disorder (e.g., von Willebrand's disease)
  * Acquired bleeding disorder diagnosed within the past year (e.g. acquired anti-factor VIII antibodies)

Hepatic

* Bilirubin ≤ 2.0 times upper limit of normal (ULN)
* ALT and AST ≤ 2.5 times ULN

Renal

* Creatinine ≤ 1.5 times ULN
* Total serum or ionized calcium normal (supplementation allowed)

Cardiovascular

* Heart rate ≥ 50 beats/minute by EKG
* No myocardial infarction within the past 6 months
* No uncontrolled angina within the past 3 months
* No congestive heart failure within the past 3 months
* No diagnosed or suspected congenital long QT syndrome
* No history of clinically significant ventricular arrhythmias (e.g., ventricular tachycardia, ventricular fibrillation, or torsades de Pointes)
* No prolonged QTc interval (i.e., \> 450 msec) by EKG using Bazett's correction

  * High Bazett's correction (i.e., \> 450 msec) allowed provided Fridericia correction is ≤ 450 msec
* No history of second or third degree heart block

  * Pacemaker allowed
* No uncontrolled hypertension
* No other uncontrolled or significant cardiovascular disease

Other

* Not pregnant
* No nursing during and for ≥ 3 months after study participation
* Negative pregnancy test
* Fertile patients must use effective contraception for ≥ 1 month before, during, and for ≥ 3 months after study participation
* Magnesium and potassium normal (supplementation allowed)
* No serious uncontrolled medical disorder or active infection that would preclude study participation
* No dementia or altered mental status that would preclude giving informed consent
* No significant bleeding from the gastrointestinal tract within the past 6 months
* No evidence of organ dysfunction or any clinically significant deviation from normal on physical examination, vital signs, EKG, or clinical laboratory determinations unrelated to CML that would preclude study participation
* No prisoners or patients who are involuntarily incarcerated for treatment of either a psychiatric or physical (e.g., infectious disease) illness

PRIOR CONCURRENT THERAPY:

Biologic therapy

* More than 14 days since prior interferon

Chemotherapy

* More than 14 days since prior cytarabine
* Prior or concurrent hydroxyurea for elevated WBC (i.e., WBC \> 50,000/mm\^3) allowed

Endocrine therapy

* Not specified

Radiotherapy

* Not specified

Surgery

* Not specified

Other

* More than 7 days since prior imatinib mesylate
* At least 7 days since prior and no concurrent low-dose aspirin (≤ 325 mg/day)
* At least 14 days since prior and no concurrent high-dose aspirin (\> 325 mg/day)
* More than 14 days since prior targeted small molecule anticancer agents
* More than 28 days since prior investigational or antineoplastic agents except hydroxyurea or anagrelide
* At least 5 days or 5 half-lives (whichever is greater) since prior and no concurrent drugs that carry a risk of causing torsades de Pointes, including any of the following:

  * Quinidine
  * Procainamide
  * Disopyramide
  * Amiodarone
  * Sotalol
  * Ibutilide
  * Dofetilide
  * Erythromycin
  * Clarithromycin
  * Chlorpromazine
  * Haloperidol
  * Mesoridazine
  * Thioridazine
  * Pimozide
  * Ziprasidone
  * Cisapride
  * Bepridil
  * Droperidol
  * Methadone
  * Arsenic trioxide
  * Chloroquine
  * Domperidone
  * Halofantrine
  * Levomethadyl
  * Pentamidine
  * Sparfloxacin
  * Lidoflazine
* At least 5 days or 5 half-lives (whichever is greater) since prior and no concurrent medication that directly inhibits platelet function (except anagrelide for thrombocytosis due to CML), including any of the following:

  * Dipyridamole
  * Epoprostenol
  * Epitifibatide
  * Clopidogrel
  * Cilostazol
  * Abciximab
  * Ticlopidine
* At least 5 days or 5 half-lives (whichever is greater) since prior and no concurrent anticoagulants (e.g., warfarin, heparin, or low molecular weight heparin \[e.g., danaparoid, dalteparin, tinzaparin, or enoxaparin\])

  * Concurrent prophylactic low-dose warfarin for prevention of catheter thrombosis and heparin-flush for IV lines allowed
* No prior BMS-354825
* No concurrent CYP3A4 inhibitors or inducers, including any of the following:

  * Ketoconazole
  * Ritonavir
  * Rifampin
  * Efavirenz
* No other concurrent therapy for CML