Fludarabine and Total-Body Irradiation Followed By Donor Stem Cell Transplant and Cyclosporine and Mycophenolate Mofetil in Treating HIV-Positive Patients With or Without Cancer

Inclusion Criteria:

* Patients with hematologic malignancy, lymphoma or other HIV-associated malignancy are eligible provided these criteria are met:

  * The malignancy is in complete remission or very good partial remission, defined as a significant reduction of disease with therapy and no evidence for continued tumor growth in the case of lymphoma or solid tumors
  * Highly active antiretroviral therapy (HAART) is initiated within one month of hematopoietic cell transplant
  * Viral load has decreased by \>= 1.5 logs or viral load \< 5000 copies/ml plasma on HAART therapy
  * CD4 count is allowed to be \> 100 cells/ul
* HIV infected patients without malignancy who have failed HAART are eligible provided that these criteria are met:

  * They have been treated with more than one regimen of HAART for a total of at least 6 months duration
  * The viral load is \< 50 copies/ml plasma
  * The CD4 count \< 100 cells/ul
* DONOR: Human leukocyte antigen (HLA) genotypically/phenotypically identical donor; if more than one HLA-identical sibling is available, priority will be given to donors matched for cytomegalovirus (CMV) status, ABO titer, and sex

  * Peripheral blood stem cells will be collected from donors greater than 12 years of age
  * Bone marrow will be collected from donors less than 12 years of age
* DONOR: HLA phenotypically identical unrelated donor; match grades allowed:

  * Match grade 1: Matched at allele level for HLA-A, B, C, DRB1, and DQB1
  * Match grade 2.1: Single allele disparity for HLA-A, B, C, DRB1, and DQB1

Exclusion Criteria:

* Positive serology for toxoplasma gondii on treatment or with evidence of active infection
* Patients with other disease or organ dysfunction that would limit survival to less than 30 days
* Patients with medical history of noncompliance with HAART or medical therapy
* DONOR: Donors for whom medical or psychologic reasons would make donor procedure intolerable
* DONOR: Marrow donors who have increased anesthetic risk
* DONOR: Donors who are HIV positive
* DONOR: Age \> 75 years