Clinical trial · Interventional
Healthy Exercise for Lymphoma Patients (HELP)
Randomized Controlled Trial of Exercise in Lymphoma Patients
NCT00111865CI-TRIAL-00001656HELPunknownPhase 3ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Objectives: The primary objective of this trial is to determine the effect of aerobic exercise training (AET) on change in quality of life (QoL) in lymphoma survivors receiving and not receiving chemotherapy. Secondary objectives are to determine the effects of AET on changes in psychosocial outcomes, cardiopulmonary fitness, body composition, and treatment completion rates.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lymphoma | Lymphoma | ONTOLOGY_EXACT | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Aerobic Exercise Training | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Exercise
- description
- Aerobic Exercise Training
- interventionNames
- Behavioral: Aerobic Exercise Training
- type
- NO_INTERVENTION
- label
- Usual Care
Primary outcomes (1)
- measure
- Change in QoL between baseline and postintervention.
- timeFrame
- 12 weeks
Secondary outcomes (4)
- measure
- Changes in cardiopulmonary fitness
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Non-hodgkin's lymphoma (including chronic lymphocytic leukemia) or Hodgkin's disease * Approval of the treating oncologist * Scheduled to receive no chemotherapy or chemotherapy for at least 8 weeks * Able to understand and provide written informed consent in English * 18+ years of age * No uncontrolled hypertension, cardiac illness, psychiatric condition * No contraindication to exercise as determined by a fitness test Exclusion Criteria: * Pregnant. * Transplant candidate. * Unwilling to accept randomization. * Any medical condition that would be a contraindication to exercise. The clinicians will make this decision. * Unwilling to travel to/participate in the exercise program as defined by the protocol. * Planned/known absence of greater than 2 weeks during the intended study period
References
Publications (3)
- DERIVEDCourneya KS, Forbes CC, Trinh L, Sellar CM, Friedenreich CM, Reiman T. Patient satisfaction with participation in a randomized exercise trial: effects of randomization and a usual care posttrial exercise program. Clin Trials. 2013;10(6):959-66. doi: 10.1177/1740774513495985. Epub 2013 Aug 5. PMID 23918843
- DERIVEDCourneya KS, Sellar CM, Trinh L, Forbes CC, Stevinson C, McNeely ML, Peddle-McIntyre CJ, Friedenreich CM, Reiman T. A randomized trial of aerobic exercise and sleep quality in lymphoma patients receiving chemotherapy or no treatments. Cancer Epidemiol Biomarkers Prev. 2012 Jun;21(6):887-94. doi: 10.1158/1055-9965.EPI-12-0075. Epub 2012 Apr 20. PMID 22523181
- DERIVEDCourneya KS, Stevinson C, McNeely ML, Sellar CM, Friedenreich CM, Peddle-McIntyre CJ, Chua N, Reiman T. Effects of supervised exercise on motivational outcomes and longer-term behavior. Med Sci Sports Exerc. 2012 Mar;44(3):542-9. doi: 10.1249/MSS.0b013e3182301e06. PMID 21814149