Clinical trial · Interventional
A Study of Pemetrexed Plus Doxorubicin Given to Patients With Advanced Breast Cancer
A Phase 2 Study of ALIMTA Plus Doxorubicin Administered Every 21 Days in Patients With Advanced Breast Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This is a non-randomized Phase 2 study testing pemetrexed and doxorubicin in combination for locally advanced or metastatic breast cancer. Both pemetrexed and doxorubicin have been combined with other drugs, but they have not yet been combined with each other. It is expected that the patient will benefit from the different mechanisms of action of the two drugs. However, there is no guarantee that the patient will benefit from this treatment.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Doxorubicin | Drug | Doxorubicin | ALIAS |
| Pemetrexed | Drug | Pemetrexed | ALIAS |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- To assess the antitumor activity of pemetrexed plus doxorubicin, as measured by overall tumor response rate
Secondary outcomes (3)
- measure
- Time to progressive disease
- measure
- Progression-free survival
- measure
- Overall survival
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Diagnosis of locally advanced or metastatic breast cancer that is not amenable to local treatment. * Patients must be chemo-naive or have received only neoadjuvant and/or adjuvant chemotherapy. * At least one measurable lesion. * No chemotherapy within 4 weeks prior to enrollment. * Signed informed consent from the patient. Exclusion Criteria: * Prior chemotherapy for metastatic breast cancer. * Prior treatment with any anthracyclines or anthracenedione-containing regimen. * Treatment within the last 30 days with any drug that has not received regulatory approval. * Pregnancy and/or breast feeding. * Inability or unwillingness to take folic acid or vitamin B12 supplementation.
References
Publications (0)
Data not yet available