Clinical trial · Observational
Effect of Solar-Simulated Ultraviolet Radiation on Gene Expression in Unprotected and Sunscreen-Protected Skin of Healthy Adults With Fitzpatrick Skin Type II
Transcriptional Profiling of the Epidermal Response to Solar-Simulated Ultraviolet Radiation
NCT00099112CI-TRIAL-00017724completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
RATIONALE: Testing of skin that has been exposed to artificial sunlight may help in understanding the genetic processes involved in the development of skin cancer. PURPOSE: This trial is studying the effect of solar-simulated ultraviolet radiation on skin with or without sunscreen in healthy adults with skin that burns easily after only slight tanning during sun exposure.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Non-melanomatous Skin Cancer | — | UNRESOLVED | — |
| Precancerous Condition | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| biopsy | Procedure | — | UNRESOLVED |
| evaluation of cancer risk factors | Procedure | — | UNRESOLVED |
| microarray analysis | Genetic | — | UNRESOLVED |
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 45 Years
Show eligibility criteria text
DISEASE CHARACTERISTICS: * Healthy, fair-skinned adults * Fitzpatrick skin type II by history and physical exam * Skin easily burns, and tans only slightly, after sun exposure * Test site for solar-simulated ultraviolet radiation exposure (buttocks) devoid of sunburn, suntan, scars, active dermal lesions, and uneven skin tones * Nevi allowed at physician discretion * Excess hair must be clipped or shaved * No prior nonmelanoma skin cancer, melanoma, or dysplastic nevi PATIENT CHARACTERISTICS: Age * 18 to 45 Performance status * Not specified Life expectancy * Not specified Hematopoietic * Not specified Hepatic * Not specified Renal * Not specified Other * No prior malignancy * No prior phototoxic, photoallergic, or other abnormal responses to sunlight * No prior allergic reaction to sunscreen or lidocaine * No underlying disease that is known to cause immunosuppression (e.g., HIV, cancer, or post-organ transplantation) * No situation that would preclude study compliance * Not pregnant or nursing PRIOR CONCURRENT THERAPY: Biologic therapy * Not specified Chemotherapy * Not specified Endocrine therapy * Not specified Radiotherapy * Not specified Surgery * Not specified Other * More than 6 months since prior topical or systemic medication producing abnormal sunlight responses * No concurrent medications with \> 1% incidence of sun-related toxic effects * No concurrent medications associated with abnormal light response * No concurrent immunosuppressants * No other concurrent ultraviolet radiation (e.g., sunlight or tanning bed) to the epidermal test site
References
Publications (0)
Data not yet available
No reference posted for this study.