A Fish Oil Supplement to Maintain Body Weight in Patients With Disease-Related Weight Loss

Inclusion Criteria:

* Men and Women with disease-related weight loss e.g. cardiac cachexia, COPD, CHF, RA.
* All stages of Pancreatic cancer patients (No weight loss requirements)
* All stages of cancer with 5% weight loss
* At least 6 weeks post-surgery
* On a stable dose of medications for at least 6 weeks prior to study entry
* Most recent ECOG Performance status score of 0,1,2,or 3 if applicable
* Agree to use acceptable methods of contraception during the study and for 3 months after study completion, for female participants. Females with reproductive potential must have a negative urine or serum pregnancy test within 7 days of study.
* Willing to continue current therapy for cancer for the duration of the study
* If with diabetes mellitus HgbA1C of \<10%
* Adequate bone marrow function ANC\> 1000/mm3, platelets 50,000/mm3, hemoglobin, 8g/dl.
* No active infections including known history of HIV or viral hepatitis.

Exclusion Criteria:

* Esophageal Cancer
* Individuals with hypertriglyceridemia
* Life expectancy of less than 12 weeks
* Alcohol consumption more than 3 drinks/day for men or 2 drinks/day for women.
* Untreated endocrine problems
* Severe Depression
* Untreated endocrine problems, such as hypothyroidism. Gonadal dysfunction from a known primary endocrine dysfunction (e.g. Klinefelters syndrome, pituitary tumor, testicular neoplasms, testicular surgery.
* Medications that impair sex hormone synthesis, secretion, or function (e.g. spironolactone, anti-estrogens, anabolic steroids and androgens.
* Fish oils within 3 months prior to study entry.
* Any infectious disease, such as HIV or viral hepatitis.
* Vitamins in doses greater than the Recommended Daily Allowance (RDA)
* Herbs in the month prior to study entry.
* Only participation in other cachexia studies is prohibited.
* Prothrombin Time INR \> 2.5 on Coumadin and INR \> 2.0 not on Coumadin.