Clinical trial · Interventional
Combination Chemotherapy, and Radiation Therapy in Treating Patients With Locally Advanced Pancreatic Cancer
A Phase II Study Of Neo-Adjuvant Chemotherapy And Radiation In Patients With Locally Advanced Pancreatic Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
RATIONALE: Drugs used in chemotherapy work in different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Giving combination chemotherapy with radiation therapy before surgery may shrink the tumor so that it can be removed. PURPOSE: This phase II trial is studying how well giving combination chemotherapy together with radiation therapy works in treating patients who may undergo surgery for locally advanced pancreatic cancer.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Pancreatic Cancer | Malignant Pancreatic Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (8)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| adjuvant therapy | Procedure | — | UNRESOLVED |
| conventional surgery | Procedure | — | UNRESOLVED |
| fluorouracil | Drug | Fluorouracil | ALIAS |
| gemcitabine hydrochloride | Drug | Gemcitabine | ALIAS |
| leucovorin calcium | Drug | Leucovorin | ALIAS |
| neoadjuvant therapy | Procedure | — | UNRESOLVED |
| oxaliplatin | Drug | Oxaliplatin | ALIAS |
| radiation therapy | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- treatment
- description
- see interventions
- interventionNames
- Drug: fluorouracil
- Drug: gemcitabine hydrochloride
- Drug: leucovorin calcium
- Drug: oxaliplatin
- Procedure: adjuvant therapy
- Procedure: conventional surgery
- Procedure: neoadjuvant therapy
- Radiation: radiation therapy
Primary outcomes (2)
- measure
- Surgical Exploration
- timeFrame
- After 6 weeks of chemotherapy and then after 4 weeks of chemo-radiation.
- description
- Patients who completed chemotherapy \& chemo-radiation had restaging imaging studies 4 weeks after completion of chemo-radiation. If there were no contraindications for surgical resection, surgical exploration was performed 6-8 weeks after completing chemo-radiation
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 19 Years
- Maximum age
- 120 Years
Show eligibility criteria text
Inclusion Criteria: * Diagnosis of adenocarcinoma of the pancreas o Locally advanced disease * Potentially resectable disease * 19 years of age and over * Karnofsky 60-100% * Absolute granulocyte count ≥ 2,000/mm\^3 * Platelet count ≥ 100,000/mm\^3 * Bilirubin ≤ 2.0 mg/dL (in the absence of biliary obstruction) * If biliary obstruction is present, patients must undergo biliary decompression * Bilirubin ≤ 3.0 mg/dL after biliary drainage has been established * Creatinine ≤ 1.6 mg/dL Exclusion Criteria: * No early stage resectable disease * No concurrent non-steroidal anti-inflammatory medication * No evidence of distant metastases to the liver or peritoneal area according to imaging studies and laparoscopic staging * No symptomatic congestive heart failure * No unstable angina pectoris * No serious uncontrolled cardiac arrhythmia * Not pregnant or nursing * No uncontrolled illness * No active or ongoing infection requiring IV antibiotics * No marked intolerance to 5-fluoropyrimidines (i.e., fluorouracil, floxuridine, capecitabine, or fluorocytosine) * No allergy to sulfonamides, aspirin, or non-steroidal anti-inflammatory drugs * No allergy to platinum compounds or to antiemetics appropriate for administration in conjunction with study chemotherapy * No other malignancy within the past 5 years except adequately treated basal cell or squamous cell skin cancer or adequately treated noninvasive carcinoma * No prior chemotherapy for pancreatic cancer * No prior abdominal radiotherapy
References
Publications (0)
Data not yet available