Clinical trial · Interventional
In Vivo Angiostatin Generation Using Tissue Plasminogen Activator and Captopril in Treating Patients With Progressive Metastatic Cancer
Phase I/II Trial of In Vivo Angiostatin Generation With Tissue Plasminogen Activator (tPA) and Captopril in Patients With Progressive, Metastatic Cancer
NCT00086723CI-TRIAL-00007142completedPhase 1 / Phase 2ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
RATIONALE: Tissue plasminogen activator and captopril may help the body generate angiostatin. Angiostatin may stop the growth of cancer by stopping blood flow to the tumor. PURPOSE: This phase I/II trial is studying the side effects and best dose of tissue plasminogen activator and captopril and to see how well they work in treating patients with progressive metastatic cancer.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Unspecified Adult Solid Tumor, Protocol Specific | Adult Solid Neoplasm | ALIAS | 0.85 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| captopril | Drug | — | UNRESOLVED |
| recombinant tissue plasminogen activator | Biological | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Angiostatin production
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
DISEASE CHARACTERISTICS: * Diagnosis of progressive metastatic cancer, excluding hematologic malignancies (i.e., leukemia or lymphoma) * Measurable disease not required * Must have received at least 1 prior systemic treatment for metastatic disease * No known CNS involvement * CNS involvement allowed provided it is successfully controlled by prior surgery or radiotherapy and there is no current requirement for corticosteroids PATIENT CHARACTERISTICS: Age * 18 and over Performance status * ECOG 0-2 Life expectancy * At least 3 months Hematopoietic * Granulocyte count at least 1,500/mm\^3 * Platelet count at least 100,000/mm\^3 * No bleeding diathesis Hepatic * Bilirubin no greater than 1.5 mg/dL * SGOT no greater than 3 times upper limit of normal * Albumin normal * PT and aPTT normal * Fibrinogen \> lower limit of normal Renal * Creatinine no greater than 1.8 mg/dL Cardiovascular * No myocardial infarction within the past 6 months * No history of stroke, transient ischemic attack, or symptoms of cerebral ischemia * No history of angioedema with captopril * No severe or uncontrolled hypertension (i.e., systolic blood pressure greater than 180 mm Hg or diastolic blood pressure greater than 110 mm Hg) * No congestive heart failure requiring therapy * No chronic hypotension (e.g., systolic blood pressure less than 100 mm Hg) Other * Not pregnant or nursing * Fertile patients must use effective contraception * HIV negative * Potassium no greater than 5.2 mmol/L * No active internal bleeding * No history of seizures * No psychiatric disorder that would preclude the giving of informed consent or study follow-up * No other malignancy within the past 5 years except adequately treated basal cell or squamous cell skin cancer or carcinoma in situ of the cervix * No uncontrolled or active bacterial, viral, or invasive fungal infection * No recent trauma * No medical indication for anticoagulation * No contraindication to captopril PRIOR CONCURRENT THERAPY: Biologic therapy * At least 4 weeks since prior biologic therapy * No concurrent immunomodulator therapy Chemotherapy * At least 4 weeks since prior chemotherapy * No concurrent chemotherapy Endocrine therapy * See Disease Characteristics * At least 4 weeks since prior endocrine therapy Radiotherapy * See Disease Characteristics * At least 4 weeks since prior radiotherapy Surgery * See Disease Characteristics * No recent intracranial or intraspinal surgery * No concurrent surgery Other * More than 48 hours since prior anticoagulation agents (e.g., warfarin or heparin) * More than 3 weeks since prior investigational agents * No concurrent anticoagulation agents, aspirin, or nonsteroidal anti-inflammatory drugs * No other concurrent investigational agent * No concurrent phenytoin, phenobarbital, or other antiepileptic prophylaxis * Concurrent bisphosphonates allowed for metastatic bone disease
References
Publications (0)
Data not yet available
No reference posted for this study.