LMB-2 Immunotoxin in Treating Young Patients With Relapsed or Refractory Leukemia or Lymphoma

DISEASE CHARACTERISTICS:

* Histologically confirmed diagnosis of 1 of the following:

  * Non-Hodgkin's lymphoma, including the following subtypes:

    * Lymphoblastic lymphoma
    * Burkitt's lymphoma
    * Large cell lymphoma
    * Adult T-cell leukemia/lymphoma
    * Cutaneous T-cell lymphoma
    * Peripheral T-cell lymphoma
  * Hodgkin's disease
  * Acute myeloid leukemia
  * Chronic myelogenous leukemia
  * Acute lymphoblastic leukemia (ALL)

    * More than 5% blasts in the bone marrow (i.e., M2 marrow classification)
  * Acute hybrid leukemia, including the following subtypes:

    * Mixed lineage leukemia
    * Biphenotypic leukemia
    * Undifferentiated leukemia
* CD25-positive (CD25+) disease, meeting 1 of the following criteria:

  * More than 15% of malignant cells are CD25+ by immunohistochemistry with anti-CD25 antibody
  * More than 30% of malignant cells from a site are CD25+ by fluorescence-activated cell sorting analysis
* Measurable or evaluable disease
* Relapsed or refractory disease after at least 1 standard chemotherapy regimen AND 1 salvage regimen
* No available alternative curative therapies
* Ineligible for or refused hematopoietic stem cell transplantation OR disease activity that prohibits the required time to identify a suitable stem cell donor
* No CNS leukemia or lymphoma, as evidenced by any of the following criteria:

  * Cerebrospinal fluid (CSF) WBC \> 5/µl AND confirmation of CSF blasts
  * Cranial neuropathies secondary to underlying malignancy
  * CNS lymphoma detected by radiological imaging

    * Prior CNS involvement with no current evidence of CNS malignancy allowed
* No isolated testicular ALL

PATIENT CHARACTERISTICS:

Age

* 6 months to 21 years

Performance status

* ECOG 0-3 (≥ 12 years of age)
* Lansky 40-100% (\< 12 years of age)

Life expectancy

* Not specified

Hematopoietic

* Pancytopenia due to disease allowed
* For patients without bone marrow involvement:

  * Absolute neutrophil count \> 1,000/mm\^3
  * Platelet count \> 50,000/mm\^3 (transfusion independent)

Hepatic

* Bilirubin ≤ 2.0 mg/dL
* AST and ALT ≤ 5 times upper limit of normal
* Hepatitis B surface antigen negative
* Hepatitis C antibody negative

Renal

* Creatinine clearance ≥ 60 mL/min OR
* Creatinine, meeting the following age-related criteria:

  * ≤ 0.8 mg/dL (≤ 5 years of age)
  * ≤ 1.0 mg/dL (6 to 10 years of age)
  * ≤ 1.2 mg/dL (11 to 15 years of age)
  * ≤ 1.5 mg/dL (\> 15 years of age)
* Calcium 2.0-2.9 mmol/L

Cardiovascular

* Ejection fraction ≥ 45% by MUGA OR
* Shortening fraction ≥ 28% by echocardiogram

Pulmonary

* Oxygen saturation ≥ 90%

Other

* Sodium 130-150 mmol/L
* Potassium 3.0-5.5 mmol/L
* Magnesium 0.5-1.23 mmol/L
* HIV negative
* Not pregnant or nursing
* Negative pregnancy test
* Fertile patients must use effective contraception
* No clinically significant unrelated systemic illness that would preclude study participation
* No conditions that would preclude study compliance
* No serum that neutralizes \> 75% of the activity of 1 μg/mL of LMB-2 immunotoxin in tissue culture (due to either anti-toxin or anti-mouse immunoglobulin G antibodies)
* No active graft-vs-host disease (i.e., off immunosuppression)

PRIOR CONCURRENT THERAPY:

Biologic therapy

* Prior autologous bone marrow transplantation (BMT) allowed
* At least 100 days since prior allogeneic BMT
* At least 1 week since prior colony-stimulating factors (e.g., filgrastim \[G-CSF\], sargramostim \[GM-CSF\], or epoetin alfa)

Chemotherapy

* At least 2 weeks since prior chemotherapy (4 weeks for nitrosoureas) except intrathecal chemotherapy
* No other concurrent chemotherapy

Endocrine therapy

* Concurrent corticosteroids allowed provided the dose has been stable for the past week and does not increase during study treatment

  * Tapering or discontinuation of steroids allowed

Radiotherapy

* At least 3 weeks since prior radiotherapy unless \< 10% of marrow is irradiated and measurable disease exists outside the radiation port

Surgery

* Not specified

Other

* Recovered from all prior therapy
* At least 30 days since prior investigational agents
* Concurrent oral supplementation to maintain normal electrolyte levels allowed
* No concurrent anticoagulation therapy for disease-related conditions
* No other concurrent investigational agents