A Safety and Effectiveness Study of Vaccine Therapy in Patients With Indolent Lymphoma

Inclusion Criteria:

* Patients with previously treated or newly diagnosed follicular center cell grade I or grade II lymphoma, small lymphocytic lymphoma, MALT lymphoma, monocytoid B-cell lymphoma, Waldenstrom's macroglobulinemia, or marginal zone lymphoma with bidimensionally measurable disease;
* Part of the resected specimen must undergo routine pathologic examination to confirm the diagnosis of lymphoma. The remaining tissue must be used for the preparation of autologous HSPPC-96;
* Autologous HSPPC-96 vaccine must be successfully prepared and provided by the sponsor;
* A minimum of 2 grams of non-necrotic, resectable malignant lymphoma for HSPPC-96 preparation;
* Bidimensionally measurable disease in at least one location other than the resected lymphoid tissue;
* Life expectancy of at least 16 weeks;
* Zubrod performance status of less then or equal to 2;
* Adequate bone marrow function;
* Adequate hepatic function;
* Adequate renal function;
* Signed written informed consent;
* Patients of child-bearing potential must practice contraception, which is adequate in the opinion of the Principal Investigator;
* Patients of child-bearing potential must have a negative serum pregnancy test prior to entry into the study and must not be lactating;
* Patients must be willing to be followed at the M. D. Anderson Cancer Center during the course of treatment and follow-up;
* Electrocardiogram if none performed in the prior six months;
* Patients must have no chemotherapy, immunotherapy, radiotherapy, or experimental anti-cancer therapy within six weeks prior to starting autologous HSPPC-96 administration;
* Patients must have fully recovered from prior anti-cancer therapy;
* Tumor measurements and staging no more than 4 weeks prior to receiving the first dose of autologous HSPPC-96.

Exclusion Criteria:

* Patients with active or prior history of central nervous system lymphoma;
* Patients with serious intercurrent medical illnesses, requiring hospitalization;
* Patients with a history of primary or secondary immunodeficiency (other than related to the malignant lymphoma because treatment is dependent on functional immune system) or patients taking immunosuppressive drugs such as systemic corticosteroids;
* Women who are pregnant or lactating;
* Patients participating in another clinical trial;
* Patients receiving growth factors of any kind, including G-CSF, GM-CSF, or Epogen;
* Patients with bulky disease, defined as greater than 10 cm in diameter;
* Patients with positive HIV antibody;
* Patients with more than 4 previous treatment regimens will be excluded.