Radiolabeled Monoclonal Antibody in Treating Patients With Progressive Metastatic Androgen-Independent Adenocarcinoma (Cancer) of the Prostate

DISEASE CHARACTERISTICS:

* Histologically confirmed adenocarcinoma of the prostate

  * Metastatic disease
* Progressive disease after prior antiandrogen therapy, as evidenced by at least 1 of the following parameters:

  * New osseous lesions on bone scan
  * Greater than 25% increase in the sum of the products of the longest perpendicular diameters of the lesions OR the appearance of new lesions on MRI or CT scan
  * Rising prostate-specific antigen (PSA) despite adequate medical or surgical castration therapy

    * Consecutive increase in PSA, determined by two separate measurements taken at least 1 week apart and confirmed by a third, and if necessary, a fourth measurement
    * PSA must be ≥ 5 ng/mL and ≥ 25% above the previous nadir
* Measurable or evaluable disease
* Serum testosterone ≤ 50 ng/dL
* No confluent lesions involving axial and appendicular skeleton on bone scan ("superscan")

PATIENT CHARACTERISTICS:

Age

* Over 18

Performance status

* Karnofsky 70-100%

Life expectancy

* At least 6 months

Hematopoietic

* Absolute neutrophil count ≥ 2,000/mm\^3
* Hematocrit ≥ 30%
* Hemoglobin ≥ 10 g/dL
* Platelet count ≥ 150,000/mm\^3
* No serious hematologic illness that would preclude study participation

Hepatic

* AST ≤ 2 times upper limit of normal (ULN)
* Bilirubin ≤ 1.5 times ULN
* PTT normal
* PT normal OR
* INR normal
* No serious hepatic illness that would preclude study participation

Renal

* Creatinine ≤ 2.5 mg/dL
* Calcium ≤ 11 mg/dL
* No serious renal illness that would preclude study participation

Cardiovascular

* No New York Heart Association class III or IV heart disease
* No active angina pectoris
* No prior deep vein thrombophlebitis within the past 3 months
* No other serious cardiac illness that would preclude study participation

Pulmonary

* No pulmonary embolus within the past 3 months
* No other serious respiratory illness that would preclude study participation

Other

* Fertile patients must use effective contraception
* HIV negative
* No serious CNS illness that would preclude study participation
* No active serious infection not controlled by antibiotics
* No other serious illness that would preclude study participation

PRIOR CONCURRENT THERAPY:

Biologic therapy

* More than 2 weeks since prior red blood cell or platelet transfusions
* More than 2 weeks since prior hematopoietic growth factors
* No prior monoclonal antibody therapy except ProstaScint®
* No other concurrent monoclonal antibody-based therapy
* No concurrent medication to support platelet count (e.g., oprelvekin)

Chemotherapy

* More than 4 weeks since prior cytotoxic chemotherapy

Endocrine therapy

* See Disease Characteristics
* Concurrent luteinizing hormone-releasing hormone (LHRH) analog allowed provided 1 of the following is true:

  * Treatment is maintained during study participation
  * Treatment is terminated at least 10 weeks (for 1-month depot preparations), 24 weeks (for 3-month depot preparations), or 32 weeks (for 4-month depot preparations) prior to study entry
* More than 4 weeks since prior corticosteroids
* More than 4 weeks since prior adrenal hormone inhibitors
* Concurrent low-dose prednisone (≤ 5mg/day) for adrenal insufficiency allowed
* No concurrent finasteride

Radiotherapy

* More than 4 weeks since prior radiotherapy
* No prior radiotherapy to \> 25% of skeleton
* No prior strontium chloride Sr 89 or samarium Sm 153 lexidronam pentasodium-containing compounds (e.g., Metastron® or Quadramet®)

Surgery

* Not specified

Other

* More than 4 weeks since prior PC-SPES
* More than 4 weeks since prior investigational therapy (medications or devices)
* At least 1 week since prior aspirin and/or nonsteroidal anti-inflammatory agents possessing antiplatelet activity
* At least 1 week since prior antiplatelet medication, including the following:

  * Abciximab
  * Cilostazol
  * Clopidogrel
  * Dipyridamole
  * Ticlopidine
* No concurrent anticoagulant medications (for platelet count \< 50,000/mm\^3), including the following:

  * Dalteparin
  * Danaparoid
  * Enoxaparin
  * Heparin
  * Warfarin
* No other concurrent investigational therapy