Clinical trial · Interventional
Gemcitabine and Carboplatin Followed By Docetaxel in Treating Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer
A Phase III Study of Delayed vs. Immediate Second-Line Therapy With Docetaxel After Gemcitabine + Carboplatin in Advanced Non-Small Cell Lung Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
RATIONALE: Drugs used in chemotherapy, such as gemcitabine, carboplatin, and docetaxel, use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. It is not yet known which treatment regimen is more effective for stage IIIB or stage IV non-small cell lung cancer. PURPOSE: Randomized phase III trial to compare the effectiveness of gemcitabine and carboplatin followed immediately by docetaxel with that of giving delayed docetaxel in treating patients who have stage IIIB or stage IV non-small cell lung cancer.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| carboplatin | Drug | Carboplatin | ALIAS |
| docetaxel | Drug | Docetaxel | ALIAS |
| gemcitabine hydrochloride | Drug | Gemcitabine | ALIAS |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Immediate Docetaxel
- description
- Arm I (immediate docetaxel): Patients receive immediate docetaxel IV over 1 hour on day 1.
- interventionNames
- Drug: carboplatin
- Drug: docetaxel
- Drug: gemcitabine hydrochloride
- type
- ACTIVE_COMPARATOR
- label
- Delayed Docetaxel
- description
- Arm II (delayed docetaxel): Patients are observed until first evidence of disease progression and then receive docetaxel IV over 1 hour on day 1.
- interventionNames
- Drug: carboplatin
- Drug: docetaxel
- Drug: gemcitabine hydrochloride
Primary outcomes (1)
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
DISEASE CHARACTERISTICS:
* Histologically or cytologically confirmed non-small cell lung cancer (NSCLC)
* Stage IIIB with pleural effusion OR stage IV disease
* Recurrent disease after primary treatment with radiotherapy or surgery allowed
* Measurable disease or nonmeasurable disease
* Measurable disease, defined as at least 1 unidimensionally measurable lesion at least 20 mm by conventional techniques OR at least 10 mm by spiral CT scan
* Nonmeasurable disease, defined as all other lesions, including small lesions (longest diameter less than 20 mm by conventional techniques OR less than 10 mm by spiral CT scan) or any of the following:
* Bone lesions
* Leptomeningeal disease
* Ascites
* Pleural/pericardial effusion
* Inflammatory breast disease
* Lymphangitis cutis/pulmonis
* Cystic lesions
* Abdominal masses not confirmed and followed by imaging techniques
* No symptomatic CNS metastases
* Treated, stable CNS metastases allowed provided patient is not receiving radiotherapy or corticosteroids
PATIENT CHARACTERISTICS:
Age
* Over 18
Performance status
* ECOG 0-2
Life expectancy
* At least 12 weeks
Hematopoietic
* WBC at least 3,000/mm\^3
* Absolute neutrophil count at least 1,000/mm\^3
* Platelet count at least 100,000/mm\^3
Hepatic
* Bilirubin no greater than 1.5 mg/dL
* SGOT no greater than 3.0 times upper limit of normal (ULN) (less than 5.0 times ULN for patients with documented benign disease)
* Alkaline phosphatase less than 3.0 times ULN (for patients with documented benign disease)
Renal
* Creatinine no greater than 1.5 mg/dL
Other
* Not pregnant or nursing
* Fertile patients must use effective contraception during and for 3 months after study participation
* No active and ongoing infection
* No concurrent serious systemic disorder that would preclude study participation
* No other primary malignancy within the past 5 years except carcinoma in situ of the cervix, adequately treated basal cell skin cancer, or T1 vocal cord cancer in remission
* Other prior cancers unlikely to affect survival for the next 3 years (e.g., low-grade early stage prostate cancer) are allowed
PRIOR CONCURRENT THERAPY:
Biologic therapy
* No concurrent immunotherapy
Chemotherapy
* No prior chemotherapy for NSCLC, including neoadjuvant and adjuvant therapy
* No other concurrent chemotherapy
Endocrine therapy
* See Disease Characteristics
* No concurrent antitumor hormonal therapy (excluding contraceptives and replacement steroids)
Radiotherapy
* See Disease Characteristics
* At least 3 weeks since prior radiotherapy and recovered
* Prior radiotherapy to less than 25% of bone marrow allowed provided the irradiated area is not the only site of measurable disease
* No concurrent radiotherapy
Surgery
* See Disease Characteristics
Other
* At least 3 weeks since prior therapy for cancer
* More than 4 weeks since prior investigational agents
* No other concurrent experimental medications
* No other concurrent therapy for cancerReferences
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