Clinical trial · Interventional
A Pilot Study of OSI-461 in Patients With Chronic Lymphocytic Leukemia (CLL)
A Pilot Trial of OSI-461 in Patients With Chronic Lymphocytic Leukemia
NCT00073489CI-TRIAL-00005638completedPhase 2ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The objectives of this study are to evaluate the safety and efficacy of OSI-461 in CLL patients.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Chronic Lymphocytic Leukemia | Chronic Lymphocytic Leukemia | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| OSI-461 | Drug | — | UNRESOLVED |
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Diagnosis of CLL established by bone marrow aspiration and biopsy or flow cytometry of peripheral blood. * No previous therapy for CLL. * Expected remaining life span greater than or equal to six months. * 18 years or older. * Willingness and ability to sign an informed consent. Exclusion Criteria: * Other active malignancy or history of treatment of any malignancy (excluding non-melanoma skin cancer) within the previous three years. * History of other malignancy which could affect the diagnosis or assessment of OSI-461. * Previous therapy for CLL. * Use of an investigational medication or device within one month of initiating study therapy. * Concurrent immunotherapy. * Use of steroids at the time of enrollment (patients who require steroids after enrollment may remain on study). * Any condition or any medication which may interfere with the conduct of the study. * Serious uncontrolled intercurrent medical or psychiatric illness, including serious infection. * Evidence of CNS involvement. * Pregnant or nursing women.
References
Publications (0)
Data not yet available
No reference posted for this study.