Clinical trial · Interventional
3-AP and Gemcitabine in Treating Patients With Unresectable or Metastatic Pancreatic Cancer
A Phase II Study of Triapine in Combination With Gemcitabine in Patients With Pancreatic Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
RATIONALE: Drugs used in chemotherapy such as gemcitabine use different ways to stop tumor cells from dividing so they stop growing or die. 3-AP may stop the growth of tumor cells by blocking the enzymes necessary for tumor cell growth and may help gemcitabine kill more cancer cells by making them more sensitive to the drug. PURPOSE: This phase II trial is studying how well giving gemcitabine together with 3-AP works in treating patients with unresectable or metastatic pancreatic cancer.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Pancreatic Cancer | Malignant Pancreatic Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| gemcitabine hydrochloride | Drug | Gemcitabine | ALIAS |
| triapine | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Objective response rate (partial and complete response) as assessed by RECIST criteria
Secondary outcomes (2)
- measure
- Progression-free and overall survival
- measure
- Safety and feasibility
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
DISEASE CHARACTERISTICS: * Histologically or cytologically confirmed pancreatic cancer * Unresectable or metastatic disease * Measurable disease * Outside prior radiation ports OR within prior radiation port if evidence of disease progression after radiotherapy * No CNS metastases PATIENT CHARACTERISTICS: Age * 18 and over Performance status * ECOG 0-2 Life expectancy * More than 3 months Hematopoietic * Absolute neutrophil count at least 1,500/mm\^3 * Platelet count at least 100,000/mm\^3 * Hemoglobin at least 9 g/dL (transfusion allowed) Hepatic * Bilirubin no greater than 2.0 mg/dL * AST and ALT no greater than 3 times upper limit of normal (ULN) (5 times ULN in the presence of liver metastases) * Chronic viral hepatitis allowed Renal * Creatinine no greater than 2.0 mg/dL Cardiovascular * No myocardial infarction within the past 3 months * No uncontrolled congestive heart failure * No uncontrolled coronary artery disease * No uncontrolled arrhythmias Pulmonary * No dyspnea at rest * No dependence on supplemental oxygen Other * Not pregnant or nursing * Negative pregnancy test * Fertile patients must use effective contraception during and for 3 months after study participation * No other malignancy except any of the following: * Carcinoma in situ of the cervix treated with cone biopsy or resection * Nonmetastatic basal cell or squamous cell skin cancer * Any stage I malignancy curatively resected more than 5 years ago * No active infection * No known or suspected glucose-6-phosphate dehydrogenase deficiency * No other concurrent life threatening illness PRIOR CONCURRENT THERAPY: Biologic therapy * Prior vaccines, antibodies, cytokines, or small molecule cell signaling inhibitors allowed Chemotherapy * No prior cytotoxic chemotherapy for unresectable or metastatic pancreatic cancer Endocrine therapy * Not specified Radiotherapy * See Disease Characteristics * More than 4 weeks since prior radiotherapy and recovered * No concurrent radiotherapy Surgery * More than 3 weeks since prior surgery and recovered Other * More than 3 weeks since prior noncytotoxic treatment regimens and objective evidence of progressive disease * No other concurrent investigational drugs
References
Publications (0)
Data not yet available