GW786034 in Treating Patients With Advanced Solid Tumors

DISEASE CHARACTERISTICS:

* Histologically confirmed advanced solid tumor
* Refractory to standard therapy or for which no standard therapy exists
* No untreated leptomeningeal or brain metastases

  * Previously treated brain metastases are allowed if currently asymptomatic and patient is off steroids and antiseizure medications for more than 3 months before study entry

PATIENT CHARACTERISTICS:

Age

* 21 and over

Performance status

* Karnofsky 70-100%

Life expectancy

* At least 12 weeks

Hematopoietic

* Absolute granulocyte count at least 1,500/mm\^3
* Platelet count at least 100,000/mm\^3
* Hemoglobin at least 9 g/dL

Hepatic

* Bilirubin no greater than 1.5 mg/dL
* AST and ALT no greater than 2 times upper limit of normal (ULN) (5 times ULN if tumor involvement)

Renal

* Creatinine clearance at least 60 mL/min

Cardiovascular

* No uncontrolled hypertension (systolic blood pressure greater than 160 mm Hg or diastolic blood pressure greater than 100 mm Hg on 2 consecutive measurements separated by 1 week)
* No arterial or venous thrombosis (including cerebrovascular accident) within the past 3 months
* No myocardial infarction within the past 3 months
* No unstable angina within the past 3 months
* No cardiac angiopathy or stenting within the past 3 months
* No cardiac pacemaker

Other

* Not pregnant or nursing
* Negative pregnancy test
* Fertile patients must use effective contraception during and for 21 days after study treatment
* Able to swallow and retain oral medication
* Good venous access
* No prior or concurrent gastrointestinal disease
* No prior or concurrent condition known to interfere with the absorption, distribution, metabolism, or excretion of drugs
* No known immediate or delayed hypersensitivity reaction or idiosyncrasy to drugs chemically related to study drug
* No other unstable, pre-existing major medical condition
* No orthopedic pins or rods or other embedded metal that would preclude undergoing an MRI
* No psychological, familial, sociological, or geographical condition that would preclude study compliance

PRIOR CONCURRENT THERAPY:

Biologic therapy

* More than 4 weeks since prior immunotherapy
* Concurrent epoetin alfa allowed
* No concurrent anticancer biologic therapy

Chemotherapy

* More than 4 weeks since prior chemotherapy (6 weeks for nitrosoureas or mitomycin)
* No concurrent anticancer cytotoxic chemotherapy

Endocrine therapy

* See Disease Characteristics
* More than 4 weeks since prior hormonal or steroid therapy (other than replacement)
* No concurrent anticancer hormonal therapy (except for replacement)
* No concurrent dexamethasone or prednisone

Radiotherapy

* More than 4 weeks since prior radiotherapy
* No concurrent anticancer radiotherapy

Surgery

* More than 4 weeks since prior major surgery
* No concurrent surgery for cancer

Other

* Recovered from prior therapy
* More than 4 weeks since prior investigational agents
* More then 28 days since prior alteration of antihypertensive medications
* Concurrent bisphosphonates allowed
* No other concurrent anticancer therapy
* No concurrent antidepressants (e.g., amitriptyline, fluoxetine, or fluvoxamine)
* No concurrent oral hypoglycemics (e.g., glipizide, glyburide, rosiglitazone, or tolbutamide)
* No concurrent therapeutic anticoagulation (e.g., warfarin at therapeutic doses)

  * Low-dose anticoagulation for prophylaxis allowed
* No concurrent cyclosporine
* No concurrent grapefruit juice
* No concurrent amiodarone, mibefradil, phenobarbital, or pioglitazone
* No concurrent Hypericum perforatum (St. John's Wort)
* No concurrent rifabutin or diethyldithiocarbamate
* No concurrent gestodene, mifepristone, or modafinil
* No concurrent herbal supplements, vitamins, or non-traditional compounds