MDX-060 Monoclonal Antibody in Treating Patients With Refractory or Relapsed Lymphoma

DISEASE CHARACTERISTICS:

* Histologically confirmed B-cell or T-cell lymphoma

  * Hodgkin's lymphoma and anaplastic large cell lymphoma eligible
  * No HIV-associated lymphoma
* CD30-positive disease by biopsy, flow cytometry, or immunohistochemistry

  * At least 50% of malignant cells (specifically Reed-Sternberg cells for Hodgkin's lymphoma) must express CD30
* Must meet one of the following criteria for relapsed/refractory disease:

  * Relapsed after prior chemotherapy or radiotherapy and autologous or allogeneic bone marrow transplantation (if appropriate)

    * Relapsed disease must be within the prior irradiated field
  * Disease that is refractory to prior chemotherapy or radiotherapy with no other curative treatment option

    * Disease progression must be within the prior irradiated field
* Progressive and evaluable disease (measurable disease required for patients accrued on study after the maximum tolerated dose is determined)

PATIENT CHARACTERISTICS:

Age

* Over 12

Performance status

* ECOG 0-2

Life expectancy

* At least 12 weeks

Hematopoietic

* WBC at least 1,500/mm\^3\*
* Neutrophil count at least 1,000/mm\^3\*
* Platelet count at least 75,000/mm\^3\*
* Hemoglobin at least 8.0 g/dL\* NOTE: \*Laboratory abnormalities attributable to organ involvement by lymphoma are allowed

Hepatic

* AST no greater than 2 times upper limit of normal (ULN)\*
* Bilirubin no greater than 2.0 mg/dL (unless due to Gilbert's syndrome)\*
* Hepatitis B surface antigen negative
* Hepatitis C antibody negative NOTE: \*Laboratory abnormalities attributable to organ involvement by lymphoma are allowed

Renal

* Creatinine no greater than 2 times ULN\* NOTE: \*Laboratory abnormalities attributable to organ involvement by lymphoma are allowed

Other

* Not pregnant or nursing
* Negative pregnancy test
* Fertile patients must use effective barrier contraception during and for 9 months after study participation
* HIV negative
* No other active malignancy within the past 5 years except basal cell or squamous cell skin cancer or carcinoma in situ of the cervix
* No active significant infection
* No apparent opportunistic infection, as indicated by any of the following:

  * Purified protein derivative recently determined to be positive
  * Infectious infiltrate by chest x-ray
  * Recent changes in fever/chill patterns
  * New, unexplained neurological symptoms
* No underlying medical condition that would preclude receiving study therapy

PRIOR CONCURRENT THERAPY:

Biologic therapy

* See Disease Characteristics
* No prior anti-CD30 antibody therapy
* No other concurrent biologic therapy

Chemotherapy

* See Disease Characteristics
* At least 4 weeks since prior chemotherapy
* No concurrent chemotherapy

Endocrine therapy

* No concurrent systemic steroidal therapy (excluding physiologic doses)

Radiotherapy

* See Disease Characteristics
* At least 4 weeks since prior radiotherapy
* No concurrent radiotherapy

Surgery

* Not specified

Other

* No other concurrent investigational agents