Adjuvant Hepatic Arterial Infusion and Combination Chemotherapy in Treating Patients With Resectable Hepatic Metastases From Colorectal Cancer

Subject Inclusion Criteria:

* History of histologically confirmed colorectal adenocarcinoma metastatic to the liver with no clinical or radiographic evidence of extrahepatic disease. Confirmation of diagnosis must be performed at MSKCC.
* Potentially completely resectable hepatic metastases without current evidence of other metastatic disease.
* Abdominal and pelvic CT scans and chest CT or x-ray within 6 weeks prior to registration. (MRI of abdomen may be substituted for CT of abdomen.)
* Lab values within 14 days prior to registration:
* WBC ≥ 3.0 K/ul
* ANC \>1.5 K/ul
* Platelets ≥ 100 K/ul
* Total bilirubin ≤ 1.5 mg/dl.
* Prior chemotherapy is acceptable if last dose given ≥ 3 weeks prior to registration to this study.
* KPS ≥ 60%
* Signed informed consent.

Subject Exclusion Criteria:

* Prior radiation to the liver. (Prior radiation therapy to the pelvis is acceptable if completed at least 4 weeks prior to registration.)
* Active infection, ascites, hepatic encephalopathy
* Prior oxaliplatin or cisplatin or HAI FUDR
* Female patients who are pregnant or lactating