Clinical trial · Interventional
Alvocidib, Fludarabine Phosphate, and Rituximab in Treating Patients With Lymphoproliferative Disorders or Mantle Cell Lymphoma
A Phase I Study of Flavopiridol, Fludarabine and Rituximab in Indolent B-cell Lymphoproliferative Disorders and Mantle Cell Lymphoma
NCT00058227CI-TRIAL-00010569completedPhase 1ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This phase I trial studies the side effects, best way to give, and the best dose of alvocidib when given together with fludarabine phosphate and rituximab in treating patients with previously untreated or relapsed lymphoproliferative disorders or mantle cell lymphoma. Monoclonal antibodies such as rituximab can locate cancer cells and either kill them or deliver cancer-killing substances to them without harming normal cells. Drugs used in chemotherapy such as alvocidib and fludarabine use different ways to stop cancer cells from dividing so they stop growing or die. Combining monoclonal antibody therapy with chemotherapy may kill more cancer cells.
Conditions
Conditions (43)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| B-cell Chronic Lymphocytic Leukemia | Chronic Lymphocytic Leukemia | ALIAS | 0.90 |
| Contiguous Stage II Grade 1 Follicular Lymphoma | — | UNRESOLVED | — |
| Contiguous Stage II Grade 2 Follicular Lymphoma | — | UNRESOLVED | — |
| Contiguous Stage II Mantle Cell Lymphoma | — | UNRESOLVED | — |
| Contiguous Stage II Marginal Zone Lymphoma | — | UNRESOLVED | — |
| Contiguous Stage II Small Lymphocytic Lymphoma | — | UNRESOLVED | — |
| Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue | Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue | ALIAS |
Interventions
Interventions (4)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| alvocidib | Drug | Alvocidib | ALIAS |
| fludarabine phosphate | Drug | Fludarabine | ALIAS |
| pharmacological study | Other | — | UNRESOLVED |
| rituximab | Biological | Rituximab | ALIAS |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Treatment (alvocidib, fludarabine phosphate, rituximab)
- description
- Patients receive fludarabine phosphate IV over 15-30 minutes on days 1-5 and rituximab IV over 3-4 hours on day 1. Alvocidib is administered IV over 60 minutes on day 1 in cohort 1; on days 1 and 2 in cohort 2; and on days 1, 2, and 3 in cohort 3. In cohorts 4 and 5, patients receive fludarabine phosphate and rituximab as above and alvocidib IV over 30 minutes and then IV over 4 hours on day 1 of courses 2-6. Treatment repeats every 28 days for up to 6 courses in the absence of disease progression or unacceptable toxicity.
- interventionNames
- Drug: alvocidib
- Drug: fludarabine phosphate
- Biological: rituximab
- Other: pharmacological study
Primary outcomes (2)
- measure
- Maximum tolerated dose (MTD) defined as that dose level beneath the dose at which 2 or more of 6 patients experience dose limiting toxicity (DLT)
- timeFrame
- Day 28
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Histologically confirmed mantle cell lymphoma OR indolent B-cell lymphoproliferative disorders of any of the following types: * Chronic lymphocytic leukemia * Small lymphocytic lymphoma * Follicular center cell non-Hodgkin's lymphoma (grade I or II) * Marginal zone lymphoma * Waldenstrom's macroglobulinemia * Hairy cell leukemia * Previously untreated or relapsed/refractory disease * No evidence of histological transformation to an intermediate-grade or aggressive lymphoma * CD20 positive by immunoperoxidase or flow cytometry * Evaluable disease with presence of 1 of the following criteria: * Absolute lymphocyte count greater than 5,000/mm\^3 * At least 1 measurable node greater than 2 cm by computed tomography (CT) scan OR measurable disease in a lymphoid structure (spleen) * Bone marrow involvement (greater than 20% of marrow cellularity) * Performance status - Eastern Cooperative Oncology Group (ECOG) 0-2 * See Disease Characteristics * Absolute neutrophil count at least 1,500/mm\^3 * Platelet count at least 100,000/mm\^3 * Hemoglobin at least 9.0 g/dL * Bilirubin no greater than 2 times normal * Aspartate aminotransferase (AST) no greater than 2 times normal * Creatinine no greater than 2.0 mg/dL * Creatinine clearance at least 50 mL/min * No renal dysfunction that would impair tolerance or compliance with study therapy * No cardiac dysfunction that would impair tolerance or compliance with study therapy * No pulmonary dysfunction that would impair tolerance or compliance with study therapy * Not pregnant or nursing * Negative pregnancy test * Fertile patients must use effective contraception * No chronic gastrointestinal disease (e.g., Crohn's disease, ulcerative colitis, short gut syndrome) that would impair tolerability of compliance with therapy * No neurological or psychiatric dysfunction that would impair tolerability of or compliance with study therapy * At least 6 weeks since prior nitrosourea or mitomycin * No more than 6 prior courses of fludarabine * No concurrent corticosteroids as antiemetics * At least 4 weeks since prior therapy for disease * No more than 3 prior treatments for disease (not including steroids alone)
References
Publications (0)
Data not yet available
No reference posted for this study.