Epoetin Alfa in Treating Fatigue in Patients With Advanced Solid Tumors Who Are Not Receiving Chemotherapy

DISEASE CHARACTERISTICS:

* Diagnosis of stage III or IV invasive non-myeloid malignancy
* Not currently hospitalized
* At least somewhat bothered by fatigue based on self-report

  * No significant psychological distress indicated by total score of 6 or more on questions 1 and 2 of the Three-Question Screening Survey (3QSS)
  * No score less than 2 on question 3 of 3QSS indicating low level of fatigue within the past week
* No uncontrolled brain metastases or leptomeningeal involvement

PATIENT CHARACTERISTICS:

Age:

* 18 and over

Performance status:

* Eastern Cooperative Oncology Group (ECOG) 0-3

Life expectancy:

* At least 12 weeks

Hematopoietic:

* Hemoglobin at least 8.5 g/dL but no greater than 11 g/dL
* No anemia due to factors other than cancer or chemotherapy (e.g., iron or folate deficiency, hemolysis, or bleeding)
* No prior or concurrent hematological disease

Hepatic:

* Not specified

Renal:

* Not specified

Cardiovascular:

* No uncontrolled hypertension (diastolic blood pressure greater than 100 mm Hg or systolic blood pressure greater than 200 mm Hg)
* No significant uncontrolled concurrent cardiovascular disease or dysfunction not attributable to malignancy or chemotherapy
* No history of deep-vein thrombosis

Pulmonary:

* No significant uncontrolled concurrent pulmonary disease or dysfunction not attributable to malignancy or chemotherapy

Other:

* Not pregnant or nursing
* Fertile patients must use effective contraception during and for 3 months after study participation
* Able to understand and complete self-report symptom assessment forms in English
* No serious concurrent infection
* No known hypersensitivity to mammalian cell-derived products or human albumin
* No uncontrolled seizures
* No significant uncontrolled concurrent endocrine, neurologic, gastrointestinal, or genitourinary system disease or dysfunction not attributable to malignancy or chemotherapy

PRIOR CONCURRENT THERAPY:

Biologic therapy:

* See Chemotherapy
* More than 4 weeks since prior biologic therapy (e.g., interferon or interleukin-2)
* More than 2 months since prior red blood cells (RBC) transfusion
* More than 1 month since prior epoetin alfa or investigational forms of epoetin alfa (e.g., gene-activated, novel erythropoiesis-stimulating protein)
* Concurrent non-myelosuppressive therapy (e.g., monoclonal antibody infusions, antiangiogenesis inhibitors, or signal transduction inhibitors) allowed
* No other concurrent biologic therapy

Chemotherapy:

* No prior high-dose chemotherapy (e.g., with bone marrow or stem cell transplantation)
* More than 4 weeks since prior chemotherapy
* No concurrent chemotherapy

Endocrine therapy:

* Concurrent hormonal therapy allowed (e.g., luteinizing hormone-releasing hormone agonists or tamoxifen)

Radiotherapy:

* More than 4 weeks since prior radiotherapy
* No concurrent radiotherapy

Surgery:

* Not specified