Intravenous Interleukin-4 PE38KDEL Cytotoxin in Treating Patients With Recurrent or Metastatic Kidney Cancer, Non-Small Cell Lung Cancer, or Breast Cancer

DISEASE CHARACTERISTICS:

* Histologically confirmed recurrent or unresponsive, metastatic renal cell, non-small cell lung, or breast cancer that has been treated previously with standard surgery, radiotherapy, chemotherapy, or immunotherapy or for which no available treatment options currently exist
* Confirmed overexpression of interleukin-4 receptors
* Measurable disease (lesions greater than 10 mm by CT scan) OR
* Evaluable disease
* No prior or concurrent clinically significant brain metastases
* Hormone receptor status:

  * Not specified

PATIENT CHARACTERISTICS:

Age:

* 18 and over

Sex:

* Male or female

Menopausal status:

* Not specified

Performance status:

* Karnofsky 70-100%

Life expectancy:

* More than 12 weeks

Hematopoietic:

* Absolute neutrophil count at least 1,500/mm\^3
* Platelet count at least 100,000/mm\^3

Hepatic:

* Bilirubin no greater than 1.5 times upper limit of normal (ULN)
* Transaminases no greater than 1.5 times ULN
* Albumin at least 2.5 g/dL
* Hepatitis B surface antigen negative
* Hepatitis C antibody negative
* No prior or concurrent hepatic disease (e.g., hepatitis or alcoholic liver disease)

Renal:

* Creatinine no greater than 2.0 mg/dL

Cardiovascular:

* See Surgery
* Electrocardiogram normal
* MUGA scan normal
* No congestive heart failure
* No cardiac arrhythmia requiring treatment
* No myocardial infarction
* No clinical evidence of coronary artery disease (unless there is a cardiac evaluation and evidence of adequate coronary function by a stress test or angiography)

Other:

* Not pregnant or nursing
* Negative pregnancy test
* Fertile patients must use effective contraception for 4 weeks before, during, and for at least 3 months after study
* No concurrent underlying medical condition that would preclude study or cannot be controlled
* No active infection

PRIOR CONCURRENT THERAPY:

Biologic therapy:

* See Disease Characteristics

Chemotherapy:

* See Disease Characteristics
* At least 4 weeks since prior chemotherapy (6 weeks for nitrosoureas or mitomycin)

Endocrine therapy:

* Not specified

Radiotherapy:

* See Disease Characteristics
* At least 4 weeks since prior radiotherapy

Surgery:

* See Disease Characteristics
* At least 1 year since prior surgery or angioplasty for coronary artery disease

Other:

* At least 28 days since prior experimental drugs and recovered