Vaccine Therapy With or Without Sargramostim in Treating Patients With High-Risk or Metastatic Melanoma

DISEASE CHARACTERISTICS:

* Histologically confirmed high-risk stage III or IV melanoma

  * Stage III disease less than 6 months after surgical resection

    * Completed prior interferon alfa therapy OR
    * Progressive disease or major adverse events during prior interferon alfa therapy
  * Stage III disease at least 6 months after surgical resection

    * Declined, failed, or completed prior standard therapy
  * Stage IV disease

    * Declined, failed, or completed prior standard therapy
* HLA-A2 positive
* No CNS metastases unless treated and stable

PATIENT CHARACTERISTICS:

Age:

* 18 and over

Performance status:

* Karnofsky 80-100%

Life expectancy:

* At least 4 months

Hematopoietic:

* Neutrophil count at least 1,500/mm3
* Lymphocyte count at least 500/mm3
* Platelet count at least 100,000/mm3
* Hemoglobin at least 9.0 g/dL (10.0 g/dL if less than 50 kg)
* No bleeding disorder

Hepatic:

* Bilirubin no greater than 2.0 mg/dL
* No hepatitis B or C positivity

Renal:

* Creatinine no greater than 1.8 mg/dL

Cardiovascular:

* No New York Heart Association class III or IV heart disease

Other:

* HIV negative
* No other serious illness
* No serious infection requiring antibiotics
* No history of immunodeficiency disease or autoimmune disease
* No psychiatric or addictive disorder that would preclude study
* Not pregnant or nursing
* Negative pregnancy test
* Fertile patients must use effective contraception

PRIOR CONCURRENT THERAPY:

Biologic therapy:

* See Disease Characteristics
* No prior bone marrow or stem cell transplantation
* At least 4 weeks since prior immunotherapy or biologic therapy
* No other concurrent immunotherapy or biologic therapy

Chemotherapy:

* At least 4 weeks since prior chemotherapy (6 weeks for nitrosoureas)
* No concurrent chemotherapy

Endocrine therapy:

* No concurrent systemic corticosteroids
* No concurrent steroids except topical or inhalational steroids
* Concurrent hormonal therapy allowed

Radiotherapy:

* At least 4 weeks since prior radiotherapy

Surgery:

* See Disease Characteristics
* At least 4 weeks since prior surgery

Other:

* At least 4 weeks since prior investigational agents
* Concurrent noncytotoxic anticancer therapy allowed
* No concurrent immunosuppressive therapy
* No concurrent antihistamines
* No concurrent non-steroidal anti-inflammatory drugs except in low doses for prevention of an acute cardiovascular event or pain control