Vaccine Therapy in Treating Patients With Melanoma of the Eye

DISEASE CHARACTERISTICS:

* Diagnosis of ocular melanoma

  * No melanoma of the iris
* Disease adequately treated by prior surgery (enucleation or tumorectomy) and/or radiotherapy

  * No more than 5 weeks since the beginning of primary tumor treatment
* Measurable disease

  * At least 12.0 mm in largest diameter OR
  * At least 6.0 mm in height
* HLA-A2 positive
* No distant metastases

PATIENT CHARACTERISTICS:

Age:

* Over 18

Performance status:

* ECOG 0-1

Life expectancy:

* Not specified

Hematopoietic:

* Hemoglobin at least 9 g/dL
* Neutrophil count at least 2,000/mm\^3
* Lymphocyte count at least 700/mm\^3
* Platelet count at least 100,000/mm\^3
* No bleeding disorder

Hepatic:

* Bilirubin no greater than 2.0 mg/dL
* AST and ALT no greater than 2 times upper limit of normal (ULN)
* Lactate dehydrogenase no greater than 2 times ULN
* Alkaline phosphatase no greater than 2 times ULN
* Gamma glutamyl transpeptidases no greater than 2 times ULN
* Hepatitis C antibody negative
* Hepatitis B antigen negative

Renal:

* Creatinine no greater than 2.0 mg/dL

Immunologic:

* No clinical immunodeficiency
* No autoimmune diseases
* No inflammatory bowel disease
* No active infection requiring antibiotics
* No multiple sclerosis

Other:

* HIV negative
* No other malignancy except surgically cured carcinoma in situ of the cervix or basal cell or squamous cell carcinoma of the skin
* No other uncontrolled illness
* No psychological, familial, sociological, or geographical conditions that would preclude study participation
* Not pregnant or nursing
* Negative pregnancy test
* Fertile patients must use effective contraception during and for at least 3 months after study participation

PRIOR CONCURRENT THERAPY:

Biologic therapy:

* No other concurrent immunotherapy or biologic therapy

Chemotherapy:

* No concurrent chemotherapy

Endocrine therapy:

* At least 3 weeks since prior steroids
* No concurrent chronic therapy with high doses of corticosteroids (e.g., methylprednisolone at least 12 mg/day)
* Concurrent topical or inhalation steroids allowed
* No concurrent hormonal therapy

Radiotherapy:

* See Disease Characteristics
* Prior proton beam therapy allowed
* Prior brachytherapy without tumor resection allowed
* Recovered from prior radiotherapy
* No prior radiotherapy to the spleen
* No prior pre-enucleation radiotherapy
* No prior ruthenium Ru 106 as primary therapy alone
* No concurrent radiotherapy

Surgery:

* See Disease Characteristics
* Prior transcleral tumor resection allowed
* Recovered from prior surgery
* No prior major organ allograft
* No prior splenectomy

Other:

* No other concurrent investigational drugs
* No concurrent systemic immunosuppressive drugs