Clinical trial · Interventional
Bortezomib and Paclitaxel in Treating Patients With Locally Advanced or Metastatic Solid Tumors
A Phase I Study of PS-341 in Combination With Paclitaxel in Metastatic Solid Tumors
NCT00030368CI-TRIAL-00010560completedPhase 1ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Phase I trial to study the effectiveness of combining bortezomib with paclitaxel in treating patients who have advanced or metastatic solid tumors. Bortezomib may stop the growth of cancer cells by blocking the enzymes necessary for their growth. Drugs used in chemotherapy work in different ways to stop tumor cells from dividing so they stop growing or die. Combining bortezomib with paclitaxel may kill more tumor cells.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Unspecified Adult Solid Tumor, Protocol Specific | Adult Solid Neoplasm | ALIAS | 0.85 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| bortezomib | Drug | Bortezomib | ALIAS |
| laboratory biomarker analysis | Other | — | UNRESOLVED |
| paclitaxel | Drug | Paclitaxel | ALIAS |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Treatment (bortezomib, paclitaxel)
- description
- Patients receive bortezomib IV on days 2 and 9 and paclitaxel IV over 1 hour on days 1 and 8. For the first course only, patients do not receive paclitaxel on day 1. Courses repeat every 3 weeks in the absence of disease progression or unacceptable toxicity.
- interventionNames
- Drug: bortezomib
- Drug: paclitaxel
- Other: laboratory biomarker analysis
Primary outcomes (3)
- measure
- Dose-limiting toxicity (DLT) defined as Common Terminology Criteria (CTC) version 2.0 grade 3 or greater non-hematologic toxicity or grade 4 hematologic toxicity with the exception of asymptomatic neutropenia [ANC < 500]
- timeFrame
- 21 days
- measure
- Maximum-tolerated dose (MTD) based on the incidence of DLT
- timeFrame
- 21 days
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Histologically or cytologically confirmed locally advanced or metastatic solid tumor for which there is no curative treatment * No known brain metastases * Performance status - ECOG 0-2 * Performance status - Karnofsky 60-100% * WBC at least 3,000/mm\^3 * Absolute neutrophil count at least 1,500/mm\^3 * Platelet count at least 100,000/mm\^3 * Bilirubin normal * AST/ALT no greater than 2.5 times upper limit of normal (ULN) * Creatinine no greater than ULN * Left ventricular function at least lower limit of normal if received prior doxorubicin * No grade II or IV tilt-table test * No symptomatic congestive heart failure * No unstable angina pectoris * No cardiac arrhythmia * No thrombotic event within the past 6 months * Not pregnant or nursing * Negative pregnancy test * Fertile patients must use effective contraception * No prior allergic reaction to compounds of similar chemical or biological composition to study drugs * No other concurrent uncontrolled illness * No ongoing or active infection * No psychiatric illness or social situation that would preclude study compliance * At least 4 weeks since prior chemotherapy (6 weeks for nitrosoureas or mitomycin) * Prior paclitaxel allowed * At least 2 weeks since prior hormonal therapy * No concurrent steroids or hormonal therapy except steroids to prevent hypersensitivity reactions to paclitaxel or hormonal therapy for non-disease-related conditions (e.g., insulin for diabetes) * At least 4 weeks since prior radiotherapy * At least 4 weeks since prior surgery * Recovered from prior therapy * No other concurrent investigational agents * No concurrent combination anti-retroviral therapy for HIV-positive patients * No concurrent anticoagulation therapy * Concurrent pamidronate or zoledronate allowed for treatment of hypercalcemia or for palliation of skeletal metastases
References
Publications (0)
Data not yet available
No reference posted for this study.