Clinical trial · Interventional
Curcumin for the Prevention of Colon Cancer
Phase I Pharmacokinetic Trial of Curcuminoids Administered in a Capsule Formulation
NCT00027495CI-TRIAL-00008719completedPhase 1ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development of cancer. Curcumin may be effective in preventing the development of colon cancer. PURPOSE: Phase I trial to determine the dose amount of curcumin that can be tolerated to help in preventing colon cancer in healthy men and women.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| curcumin | Dietary Supplement | — | UNRESOLVED |
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
DISEASE CHARACTERISTICS: * Healthy men and women age 18 and over PATIENT CHARACTERISTICS: Age: * 18 and over Performance status: * Not specified Life expectancy: * Not specified Hematopoietic: * WBC greater than 4,000/mm3 * Hemoglobin greater than 12 g/dL * Platelet count greater than 120,000/mm3 Hepatic: * ALT/AST less than 1.5 times upper limit of normal (ULN) * Alkaline phosphatase less than 1.5 times ULN * Bilirubin less than 1.5 mg/dL Renal: * Creatinine less than 1.7 mg/dL Other: * Not pregnant or nursing * Negative pregnancy test * Fertile patients must use effective contraception * No prior cancer except surgically resected basal cell or squamous cell skin cancer * No history of peptic ulcer disease, gastrointestinal bleeding from gastric or duodenal ulcers, or gastrin secreting tumors * No history of unreliability or noncompliance (missing pretreatment appointment more than twice) PRIOR CONCURRENT THERAPY: Biologic therapy: * Not specified Chemotherapy: * Not specified Endocrine therapy: * At least 14 days since prior steroids Radiotherapy: * Not specified Surgery: * Not specified Other: * At least 14 days since prior curcumin (turmeric) rich foods * At least 14 days since prior nonsteroidal antiinflammatory drugs (NSAIDs) * No chronic medications (i.e., daily for more than 28 days) except for oral contraceptives * No concurrent coumadin or other anticoagulants
References
Publications (0)
Data not yet available
No reference posted for this study.