Clinical trial · Interventional
Radiation Therapy and Tamoxifen in Treating Children With Newly Diagnosed Brain Stem Glioma
Treatment of Children With Newly Diagnosed Diffuse Pontine Gliomas Using Conventional Radiotherapy and High Dose Tamoxifen
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Tamoxifen may kill tumor cells by blocking the enzymes necessary for cell growth. Combining radiation therapy with tamoxifen may be effective in treating newly diagnosed brain stem glioma. PURPOSE: Phase II trial to study the effectiveness of combining radiation therapy and tamoxifen in treating children who have newly diagnosed brain stem glioma.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Brain and Central Nervous System Tumors | Central Nervous System Neoplasm | ONTOLOGY_EXACT | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| radiation therapy | Radiation | — | UNRESOLVED |
| tamoxifen citrate | Drug | Tamoxifen | ALIAS |
Eligibility
Eligibility (as posted)
- Sex
- All
- Maximum age
- 19 Years
Show eligibility criteria text
DISEASE CHARACTERISTICS:
* Newly diagnosed tumor of the brain stem (diffuse intrinsic lesion centered on the pons)
* Radiological and clinical diagnostic criteria allowed (biopsy not required)
* The following astrocytic tumors are allowed if histologically confirmed:
* Diffuse astrocytoma (all subtypes)
* Anaplastic astrocytoma
* Glioblastoma
* Pilocytic astrocytoma (grade I)
* Less than 6 months since diagnosis
* At least 1 of the following signs of brain stem tumor:
* Cranial nerve deficit
* Long tract signs
* Ataxia
* No focal lesions of the brain stem (either clearly marginated or cystic), cervicomedullary tumors, tumors predominately exophytic, or pontine tumors diagnosed as pilocytic on biopsy
PATIENT CHARACTERISTICS:
Age:
* Under 20
Performance status:
* Not specified
Life expectancy:
* Not specified
Hematopoietic:
* Not specified
Hepatic:
* Not specified
Renal:
* Not specified
Other:
* Not pregnant or nursing
* No frequent vomiting or other medical condition that would preclude oral medication intake
PRIOR CONCURRENT THERAPY:
Biologic therapy:
* Not specified
Chemotherapy:
* No prior chemotherapy for brain stem glioma
Endocrine therapy:
* Concurrent steroids allowed
Radiotherapy:
* No prior radiotherapy for brain stem glioma
Surgery:
* Not specified
Other:
* Concurrent anticonvulsants allowedReferences
Publications (0)
Data not yet available