Vaccine Therapy in Treating Patients With Stage IV Head and Neck Cancer

DISEASE CHARACTERISTICS:

* Histologically confirmed stage IV squamous cell carcinoma of the oral cavity or oropharynx or nodal or dermal metastases for which current available treatment is not likely to offer a survival advantage or result in significant palliation

  * Unresectable locoregional recurrence after maximum radiotherapy OR
  * Local disease with unresectable distant metastases involving:

    * Base of skull
    * Prevertebral fascia
    * Deep neck muscles
    * Carotid artery (requiring resection)
    * Nasopharynx and/or pterygoid muscles
* Ineligible to receive radiotherapy to head and neck during study
* Primary intraoral lesions must be measurable and accessible to intralesional injections
* No metastatic brain lesions, cerebral metastasis, or leptomeningeal disease

PATIENT CHARACTERISTICS:

Age:

* 18 and over

Performance status:

* Zubrod 0-2

Life expectancy:

* At least 2 months

Hematopoietic:

* Absolute neutrophil count greater than 1,000/mm\^3
* Platelet count greater than 100,000/mm\^3
* Hemoglobin greater than 8 g/dL

Hepatic:

* Bilirubin less than 1.5 mg/dL
* AST/ALT less than 4 times upper limit of normal (ULN)
* PT/PTT less than 1.5 times ULN

Renal:

* Creatinine less than 2.0 mg/dL OR
* Creatinine clearance greater than 60 mL/min

Cardiovascular:

* No evidence of congestive heart failure
* No serious cardiac dysrhythmia
* No evidence of recent prior myocardial infarction on EKG
* No clinical coronary artery disease

Neurologic:

* No history of seizures or concurrent seizure disorder
* No evidence of encephalitis, multiple sclerosis, or other structural brain lesion(s) by clinical or radiological evaluation

Immunologic:

* No risk of immune system compromise
* HIV negative
* No hypersensitivity to eggs
* No significant history of allergies (e.g., anaphylaxis or angioedema)

Other:

* No active or chronic infection
* No other serious concurrent medical illness
* No other malignancy unless previously treated with curative intent and no evidence of persistent or recurrent disease
* Not pregnant or nursing
* Negative pregnancy test
* Fertile patients must use effective contraception

PRIOR CONCURRENT THERAPY:

Biologic therapy:

* At least 4 weeks since prior immunotherapy and recovered

Chemotherapy:

* No more than 2 prior chemotherapy regimens
* At least 4 weeks since prior chemotherapy and recovered

Endocrine therapy:

* At least 4 weeks since prior systemic corticosteroids
* No concurrent systemic corticosteroids

Radiotherapy:

* See Disease Characteristics
* At least 4 weeks since prior radiotherapy and recovered
* No prior radiotherapy to more than 50% of nodal groups

Surgery:

* More than 4 weeks since prior surgery for primary or metastatic lesions and recovered
* No prior splenectomy