Inhaled Doxorubicin in Treating Patients With Advanced Solid Tumors Affecting the Lungs

DISEASE CHARACTERISTICS:

* Histologically proven advanced cancer not curable by standard chemotherapy, radiotherapy, or surgery

  * Clinical evidence of primary lung or tracheal cancer OR
  * Metastatic cancer to the lung
* Extrathoracic metastases eligible if following criteria are met:

  * Sites are stable
  * Pulmonary sites are primary life-threatening sites
  * Evidence that study treatment may benefit the patient
* Measurable or evaluable disease
* No germ cell tumor, leukemia, or lymphoma involving the lungs that is treatable with systemic agents
* No complete atelectasis due to high-grade airway obstruction

PATIENT CHARACTERISTICS:

Age:

* 18 and over

Performance status:

* ECOG 0-1

Life expectancy:

* More than 3 months

Hematopoietic:

* Absolute neutrophil count at least 1,500/mm\^3
* Platelet count at least 100,000/mm\^3
* Hemoglobin at least 10 g/dL

Hepatic:

* Bilirubin no greater than 1.0 mg/dL
* AST and ALT less than 1.5 times upper limit of normal

Renal:

* Creatinine no greater than 1.6 mg/dL OR
* Creatinine clearance at least 60 mL/min

Cardiovascular:

* LVEF at least 40% by MUGA scan or echocardiogram
* No unstable angina, congestive heart failure, or symptomatic arrhythmias

Pulmonary:

* DLCO at least 50% predicted
* FVC and FEV1 at least 50% predicted
* Resting oxygen saturation at least 90%
* Exercise oxygen saturation at least 85%
* Oxygen consumption greater than 50% predicted
* No prior radiation pneumonitis
* No asthma
* No radiation-induced pulmonary damage

Other:

* No hypersensitivity to doxorubicin
* Not pregnant or nursing
* Negative pregnancy test
* Fertile patients must use effective contraception during and for 6 months after study
* HIV negative
* No congenital problems (e.g., cleft palate) or other anomalies that prevent tight fit of a mouthseal

PRIOR CONCURRENT THERAPY:

Biologic therapy:

* At least 4 weeks since prior biologic therapy and recovered
* No prior trastuzumab (Herceptin)

Chemotherapy:

* See Disease Characteristics
* At least 4 weeks since prior chemotherapy and recovered
* Prior doxorubicin allowed if LVEF at least 40% by MUGA scan or echocardiogram
* No prior mitomycin, bleomycin, or nitrosoureas
* No other concurrent systemic chemotherapy

Endocrine therapy:

* Not specified

Radiotherapy:

* See Disease Characteristics
* At least 4 weeks since prior radiotherapy and recovered
* At least 12 months since prior radiotherapy to chest
* No prior radiotherapy to more than 20% of total lung volume
* Prior chest wall or primary breast radiotherapy allowed
* Prior radioactive iodine allowed
* No concurrent thoracic radiotherapy

Surgery:

* See Disease Characteristics
* No prior total pneumonectomy

Other:

* No other concurrent experimental drug