Vaccine Therapy in Treating Patients With Stage III Non-Small Cell Lung Cancer

DISEASE CHARACTERISTICS:

* Histologically confirmed stage IIIA or IIIB non-small cell lung cancer (NSCLC) with one of the following p53 mutations:

  * Point mutation altering the protein sequence
  * Frame-shift mutation with the generation of a novel sequence
* No significant pleural effusions visible on plain chest radiography
* Must have completed or plan to undergo curative intent therapy for NSCLC

  * At least 2 courses of neoadjuvant chemotherapy for patients with known N2 or N3 resectable disease OR
  * At least 55 Gy radiotherapy with concurrent or sequential chemotherapy for patients with unresectable disease
  * Patients with incidental N2 or N3 disease at time of surgery may receive optional adjuvant chemotherapy and radiotherapy

PATIENT CHARACTERISTICS:

Age:

* Not specified

Performance status:

* ECOG 0-1

Life expectancy:

* Not specified

Hematopoietic:

* Lymphocyte count greater than 475/mm\^3
* Granulocyte count greater than 1,000/mm\^3
* Platelet count greater than 100,000/mm\^3

Hepatic:

* Bilirubin less than 2.0 mg/dL
* SGOT less than 3 times normal
* Albumin at least 3.0 g/dL
* No signs of acute hepatitis B infection

  * Hepatitis B surface antigen positive allowed provided there are no signs of chronic active hepatitis
* No prior hepatitis C infection

Renal:

* Creatinine less than 2.5 mg/dL
* Calcium less than 11.0 mg/dL (corrected for albumin)

Cardiovascular:

* No myocardial infarction or significant ventricular arrhythmias within the past 6 months

Other:

* No other malignancy within the past 5 years unless curatively treated and probability of recurrence is less than 5%
* HIV negative
* No psychiatric or other condition that would preclude study
* No serious ongoing infection
* No other serious medical condition that would limit life expectancy to less than 2 years
* Not pregnant or nursing
* Negative pregnancy test
* Fertile patients must use effective contraception

PRIOR CONCURRENT THERAPY:

Biologic therapy:

* Not specified

Chemotherapy:

* See Disease Characteristics
* At least 4 weeks since prior chemotherapy and no anticipated need for chemotherapy for at least 2 months after vaccinations

Endocrine therapy:

* At least 4 weeks since prior supraphysiologic steroids and no anticipated need for steroid therapy for at least 2 months after vaccinations

Radiotherapy:

* See Disease Characteristics
* At least 4 weeks since prior radiotherapy and no anticipated need for radiotherapy for at least 2 months after vaccinations

Surgery:

* See Disease Characteristics

Other:

* No influenza vaccination if egg allergy present
* At least 4 weeks and no greater than 24 weeks since completion of all prior modalities for primary therapy