Vaccine Therapy With or Without Interleukin-2 in Treating Patients With Locally Advanced or Metastatic Colorectal Cancer

DISEASE CHARACTERISTICS:

* Histologically confirmed locally advanced or metastatic colorectal cancer
* Metastatic disease must be radiologically proven
* HLA-A2-1 positive
* Locally advanced disease must have had prior resection or incomplete resection with poor prognosis
* Locally advanced disease includes:

  * Stage III or IV colon cancer (T4 or any T, N2-3, M0)
  * Stage III or IV rectal cancer (T4 or T3, N1-3)
  * Resectable or unresectable T4 disease after radiotherapy, chemotherapy, and/or surgery
  * Absence of measurable disease but more than a 50% chance of recurrence
* Completely resected or locally advanced disease may have had conventional therapy completed within 1-12 months (surgery alone, with or without adjuvant chemotherapy and/or radiotherapy) prior to study entry
* Metastatic disease patients must have bidimensionally measurable disease

  * Bone lesions with well-demarcated borders allowed
  * Lesions seen only on bone scan, pleural effusions, ascites, and changes in carcinoembryonic antigen are not considered measurable disease

PATIENT CHARACTERISTICS:

Age:

* Over 18

Performance status:

* ECOG 0-1

Life expectancy:

* Not specified

Hematopoietic:

* Lymphocyte count at least 470/mm\^3
* Granulocyte count at least 1,000/mm\^3
* Platelet count at least 100,000/mm\^3

Hepatic:

* Bilirubin no greater than 2.0 mg/dL\*
* SGOT no greater than 4 times upper limit of normal (ULN) (2.5 times ULN for adjuvant patients)\*
* Albumin at least 3 g/dL
* No active viral hepatitis
* No evidence of chronic infection due to hepatitis C
* Hepatitis B surface antigen negative NOTE: \*Unless due to metastatic disease

Renal:

* Creatinine no greater than 2.0 mg/dL

Cardiovascular:

* No history of cardiac failure, significant arrhythmias, or coronary artery disease (metastatic disease patients only)

Other:

* Not pregnant or nursing
* Fertile patients must use effective contraception
* HIV negative
* No prior malignancy with a 50% chance of recurrence within 5 years except nonmelanomatous skin cancer or carcinoma in situ of the cervix
* No medical or psychiatric condition that would preclude compliance
* No serious medical condition that would preclude apheresis
* No serious infection
* No uncontrolled thyroid disease (metastatic disease patients only)
* Patients with an allergy to eggs are allowed but are not vaccinated against influenza during study

PRIOR CONCURRENT THERAPY:

Biologic therapy:

* No prior immunologic therapy directed at the cellular immune system

Chemotherapy:

* See Disease Characteristics
* Prior chemotherapy for metastatic disease allowed
* At least 4 weeks since prior chemotherapy
* No concurrent chemotherapy or anticipated need for chemotherapy for 2 months after vaccinations

Endocrine therapy:

* At least 4 weeks since prior supraphysiologic steroid therapy

Radiotherapy:

* See Disease Characteristics
* Prior radiotherapy for metastatic disease allowed
* No concurrent radiotherapy

Surgery:

* See Disease Characteristics
* Prior surgery for metastatic disease allowed