Carboxyamidotriazole in Treating Patients With Refractory or Recurrent Ovarian Epithelial, Fallopian Tube, or Primary Peritoneal Cancer

DISEASE CHARACTERISTICS:

* Histologically confirmed refractory or recurrent ovarian epithelial, fallopian tube, or primary peritoneal cancer
* Measurable disease by physical exam, radiography, peritoneoscopy, or laparoscopy

  * No more than 4 weeks since prior peritoneoscopy
* No brain metastases

PATIENT CHARACTERISTICS:

Age:

* 18 and over

Performance status:

* ECOG 0-2

Life expectancy:

* At least 4 months

Hematopoietic:

* Absolute neutrophil count at least 1,000/mm\^3
* Platelet count at least 100,000/mm\^3
* Hemoglobin at least 9.0 g/dL AND/OR
* Hematocrit at least 27%

Hepatic:

* SGOT/SGPT no greater than 3 times upper limit of normal
* Bilirubin normal

Renal:

* Creatinine no greater than 1.5 mg/dL OR
* Creatinine clearance at least 50 mL/min

Cardiovascular:

* No history of symptomatic cardiac dysrhythmias requiring medication
* At least 6 months since prior myocardial infarction
* No unstable or newly diagnosed angina

Pulmonary:

* No obstructive lung disease requiring oxygen therapy

Other:

* Not pregnant or nursing
* HIV negative
* Must be able to take oral medication
* No concurrent medical condition (e.g., impending bowel obstruction)
* No grade 2 or greater residual peripheral neuropathy
* No active infection
* No other prior or concurrent invasive malignancy within the past 5 years
* No history of acute visual loss other than that associated with retinal detachment

PRIOR CONCURRENT THERAPY:

Biologic therapy:

* At least 4 weeks since prior cytokine therapy
* No concurrent cytokine therapy to maintain WBC count

Chemotherapy:

* At least 4 weeks since prior chemotherapy (6 weeks for nitrosoureas, carboplatin, or mitomycin)
* No other concurrent chemotherapy

Endocrine therapy:

* At least 4 weeks since prior hormonal therapy
* No concurrent corticosteroids at doses greater than physiological replacement doses
* No concurrent hormonal therapy

Radiotherapy:

* At least 4 weeks since prior radiotherapy
* No concurrent radiotherapy

Surgery:

* See Disease Characteristics

Other:

* No more than 3 prior treatment regimens
* At least 1 week since prior systemic antibiotics for infection
* No chronic antifungal treatment with antimycotic imidazoles
* No concurrent alternative therapies