Oblimersen and Gemtuzumab Ozogamicin in Treating Older Patients With Relapsed Acute Myeloid Leukemia

DISEASE CHARACTERISTICS:

* Histologically confirmed CD33+ acute myeloid leukemia (AML)

  * In first relapse from chemotherapy
  * Complete response lasting at least 3 months before relapse
* No CNS leukemia
* No secondary leukemia or history of antecedent hematologic disorder prior to initial onset of AML (e.g., myelodysplasia)

PATIENT CHARACTERISTICS:

Age:

* 60 and over

Performance status:

* ECOG 0-2

Life expectancy:

* Not specified

Hematopoietic:

* WBC less than 30,000/mm\^3
* No bleeding or coagulation disorder except disease-related disseminated intravascular coagulation

Hepatic:

* Bilirubin no greater than 1.5 mg/dL
* PT and PTT no greater than 1.5 times upper limit of normal OR
* INR no greater than 1.3
* No history of chronic hepatitis or cirrhosis

Renal:

* Creatinine no greater than 2.0 mg/dL

Cardiovascular:

* No uncontrolled congestive heart failure
* No New York Heart Association class III or IV heart disease

Pulmonary:

* No severe pulmonary disease

Other:

* HIV negative
* No other concurrent medical disease that would preclude study entry
* No known hypersensitivity to phosphorothioate-containing oligonucleotides, gemtuzumab ozogamicin or any of its components, E. coli protein, or any product produced in E. coli
* No other concurrent malignancy
* No known human anti-human antibodies
* No uncontrolled seizure disorder
* No active uncontrolled infection
* Not pregnant or nursing
* Negative pregnancy test
* Fertile patients must use effective contraception

PRIOR CONCURRENT THERAPY:

Biologic therapy:

* No prior allogeneic or autologous stem cell transplantation
* No prior therapy with an anti-CD33 antibody (e.g., gemtuzumab ozogamicin or M195)

Chemotherapy:

* See Disease Characteristics
* At least 2 weeks since prior cancer chemotherapy except intrathecal chemotherapy or hydroxyurea

Endocrine therapy:

* Not specified

Radiotherapy:

* At least 2 weeks since prior systemic radiotherapy

Surgery:

* At least 2 weeks since prior major surgery
* No prior organ allograft

Other:

* At least 3 weeks since prior antileukemic therapy and recovered
* No other concurrent investigational therapy
* No concurrent immunosuppressive therapy