Gene Therapy in Treating Patients With Colon Cancer That Has Spread to the Liver

DISEASE CHARACTERISTICS:

* Histologically confirmed adenocarcinoma of the colon

  * At least 3 metastatic hepatic lesions involving both lobes
  * No extrahepatic disease
* Failed first-line combination chemotherapy of fluorouracil plus either leucovorin calcium or irinotecan
* Herpes simplex virus type-1 seropositive
* Candidate for intrahepatic arterial infusion pump placement

PATIENT CHARACTERISTICS:

Age:

* 18 and over

Performance status:

* Karnofsky 70-100%

Life expectancy:

* Not specified

Hematopoietic:

* WBC greater than 3,000/mm\^3
* Absolute neutrophil count greater than 1,500/mm\^3
* Platelet count greater than 100,000/mm\^3
* Hemoglobin greater than 9.0 g/dL
* No history of any blood clotting disorder (e.g., hemophilia)

Hepatic:

* Transaminases no greater than 3 times upper limit of normal
* Bilirubin no greater than 2.0 mg/dL
* No active hepatitis
* No history of hepatic fibrosis, cirrhosis, or hemochromatosis

Renal:

* Creatinine no greater than 2.0 mg/dL

Other:

* Not pregnant or nursing
* Negative pregnancy test
* All patients must use effective barrier contraception during and for at least 6 months after study
* HIV negative
* No active herpes infection
* No other active uncontrolled infection
* No prior weight loss of more than 10 lbs within the past month
* No history of alcohol or other substance abuse
* No concurrent unstable and/or severe medical or psychological condition
* No history of any other medical or psychological condition that would preclude study

PRIOR CONCURRENT THERAPY:

Biologic therapy:

* At least 4 weeks since prior immunotherapy (e.g., interleukin-2, interleukin -12, or interferon)
* No prior gene transfer therapy
* No prior therapy with cytolytic virus of any type
* No concurrent immunotherapy during and for 28 days after study therapy
* No concurrent vaccines during and for 28 days after study therapy

Chemotherapy:

* See Disease Characteristics
* At least 4 weeks since prior chemotherapy (6 weeks for nitrosoureas or mitomycin)
* No concurrent chemotherapy during and for 28 days after study therapy

Endocrine therapy:

* No concurrent systemic steroids during and for 28 days after study therapy

Radiotherapy:

* No prior radiotherapy to the liver
* No concurrent radiotherapy during and for 28 days after study therapy

Surgery:

* At least 2 weeks since prior surgery

Other:

* At least 30 days since prior participation in investigational study
* No concurrent antiviral agent active against herpes simplex virus (e.g., acyclovir, valacyclovir, penciclovir, famciclovir, ganciclovir, foscarnet, or cidofovir) during and for 28 days after study therapy
* No concurrent immunosuppressive agents (e.g., cyclosporine) during and for 28 days after study therapy
* No other concurrent investigational or anti-cancer agents during and for 28 days after study therapy