Vaccine Therapy in Treating Patients With Metastatic Prostate Cancer

DISEASE CHARACTERISTICS:

* Histologically confirmed metastatic adenocarcinoma of the prostate

  * Stage D1-3
  * Regional lymph node, bone, visceral, or soft tissue metastases
  * No transitional cell or small cell carcinoma
* Testosterone less than 50 mg/L if prior treatment with luteinizing hormone releasing hormone (LHRH) analogues or estrogens
* Evidence of androgen refractory disease after surgical castration and discontinuation of LHRH analogue therapy
* No previously irradiated or new CNS metastases

PATIENT CHARACTERISTICS:

Age:

* 18 and over

Performance status:

* Karnofsky 70-100%

Life expectancy:

* More than 6 months

Hematopoietic:

* WBC at least 3,000/mm\^3
* Hemoglobin at least 9 g/dL
* Platelet count at least 100,000/mm\^3

Hepatic:

* Bilirubin less than 2.0 mg/dL
* PT at least 11.3 seconds but no greater than 13.3 seconds
* PTT at least 20.1 seconds but no greater than 32.9 seconds
* No hepatic disease
* No viral hepatitis

Renal:

* Creatinine less than 2.5 mg/dL

Cardiovascular:

* No New York Heart Association class III or IV heart disease

Pulmonary:

* No asthma
* No chronic obstructive pulmonary disease
* No severe lung disease

Other:

* No other medical illness or psychological impediment that would preclude study
* No other concurrent malignancy except nonmelanoma skin cancer or controlled superficial bladder cancer
* No active acute or chronic infection including symptomatic urinary tract infection
* No autoimmune disease (e.g., inflammatory bowel disease, systemic lupus erythematosus, rheumatoid arthritis, ankylosing spondylitis, scleroderma, or multiple sclerosis)
* HIV negative
* Adequate peripheral vein access

PRIOR CONCURRENT THERAPY:

Biologic therapy:

* Prior biologic therapy allowed
* No other concurrent immunotherapy

Chemotherapy:

* Prior chemotherapy allowed
* No concurrent chemotherapy

Endocrine therapy:

* See Disease Characteristics
* At least 4 weeks since prior non-steroidal hormonal therapy if increase in PSA while receiving non-steroidal hormonal therapy
* At least 6 weeks since prior steroids
* Concurrent LHRH analogues for gonadal androgen suppression allowed
* No concurrent steroid therapy
* No concurrent corticosteroids

Radiotherapy:

* See Disease Characteristics
* Prior palliative radiotherapy for bone metastases allowed
* Prior prostatic radiotherapy allowed
* At least 4 weeks since prior radiotherapy
* At least 12 weeks since prior strontium chloride Sr 89
* No concurrent radiotherapy

Surgery:

* See Disease Characteristics

Other:

* Recovered from prior therapy
* No concurrent immunosuppressive agents (e.g., azathioprine or cyclosporine)