Clinical trial · Observational
Genetic Study of Newly Diagnosed Central Nervous System Tumors in Young Children
Gene Expression Profiling of Infant Embryonal Central Nervous System Tumors by Microarray Gene Chip Analysis: Angiogenesis, Invasion and Metastasis
NCT00010114CI-TRIAL-00005230completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
RATIONALE: Genetic studies may help in understanding the genetic processes involved in the development of some types of cancer. PURPOSE: Genetic study to learn more about genes involved in the development of central nervous system tumors in young children.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Central Nervous System Embryonal Neoplasm | Central Nervous System Embryonal Tumor | CURATED_BROADER | 0.80 |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (1)
- label
- Newly diagnosed embryonal tumors
- description
- The participants in this study are infants (\< 3 years of age) with newly diagnosed medulloblastoma, primitive neuroectodermal tumor, or other embryonal tumor, atypical teratoid/rhabdoid tumor, intracranial germ cell tumor, or choroid plexus carcinoma who have received no prior therapy with the exception of steroids and have consented to allow research studies on banked tissue specimens
Primary outcomes (1)
- measure
- Genes that are expressed in metastatic vs. non-metastatic tumors
- timeFrame
- Prior to therapy
Secondary outcomes (1)
- measure
- Protein expression of genes found to be expressed
- timeFrame
- Prior to therapy
Eligibility
Eligibility (as posted)
- Sex
- All
- Maximum age
- 2 Years
Show eligibility criteria text
DISEASE CHARACTERISTICS: * Histologically confirmed, newly diagnosed, primary intracranial embryonal central nervous system tumor * Medulloblastoma * Primitive neuroectodermal tumor * Medulloepithelioma * Ependymoblastoma * Neuroblastoma * Pineoblastoma * Atypical teratoid/rhabdoid tumor * Intracranial germ cell tumor * Choroid plexus carcinoma * M positive ependymoma * Potential enrollment on PBTC-001 therapeutic protocol PATIENT CHARACTERISTICS: Age: * Under 3 Performance status: * Not specified Life expectancy: * Not specified Hematopoietic: * Not specified Hepatic: * Not specified Renal: * Not specified PRIOR CONCURRENT THERAPY: Biologic therapy: * Not specified Chemotherapy: * No prior chemotherapy Endocrine therapy: * Prior steroids allowed Radiotherapy: * No prior radiotherapy Surgery: * Not specified Other: * No concurrent investigational agents
References
Publications (0)
Data not yet available
No reference posted for this study.