Combination Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Patients With Mantle Cell Lymphoma

1. Documentation of Disease

   1. Histologically documented mantle cell lymphoma of any stage (needle or core biopsy is not acceptable as the sole means of diagnosis) with at least one of the following confirmatory tests indicative of diagnosis:

      * Immunophenotype with expression of CD5 and CD19 and absence of CD23
      * Cytogenetic analysis with presence of t(11;14)
      * Overexpression of cyclin D1
      * Rearrangement of BCL1 gene
   2. Rebiopsy of a node at relapse is recommended but not required.
   3. Bone marrow biopsy required for pretreatment evaluation. Bilateral biopsies are not required.
2. Identification of HLA-Matched sibling donor - The sibling donor must meet eligibility criteria outlined in section 5.0
3. Prior Therapy

   1. Patients who have failed initial therapy are eligible (without any of the poor prognostic characteristics listed in the protocol). Failure to initial treatment is defined as one of the following:

      * Failure to achieve clinical complete remission after treatment with an anthracycline-containing regimen
      * Disease recurrence after initial treatment (with an anthracycline-containing regimen)
   2. Patients in first remission must have one of the following poor prognostic characteristics:

      * International Prognostic Index (IPI) score \> 1. IPI risk factors include the following: age \> 60 (not eligible for this protocol); performance status \> 1; LDH \> normal; presence of \> 1 extranodal sites; and stage III/IV disease
      * Blastic variant of mantle cell lymphoma (regardless of IPI score)
      * Complex karyotypes (i.e., cytogenetic abnormalities different from or in addition to t(11;14) (regardless of IPI score)
      * Proliferative index \> 10% (regardless of IPI score)
      * Presence of p53 mutations
   3. Patients who have received more than two chemotherapy regimens are ineligible. Patients who have undergone a prior bone marrow transplant are not eligible.
4. Age \< 60 years
5. No active CNS lymphoma
6. DLCO ≥ 40% and no symptomatic pulmonary disease
7. No HIV infection
8. Non-pregnant and non-nursing. Treatment under this protocol would expose an unborn child to significant risks. Women and men of reproductive potential should agree to use an effective means of birth control.
9. Initial required laboratory values

   * bilirubin \< 2 mg/dl
   * AST ≤ 3 x upper limit of normal (ULN)
   * ALT ≤ 3 x ULN
   * serum creatinine \< 2 mg/dl
   * u-HCG or serum HCG negative (if patient of childbearing potential)