Celecoxib and Trastuzumab in Treating Women With Metastatic Breast Cancer

DISEASE CHARACTERISTICS:

* Histologically proven metastatic breast cancer

  * HER2/neu-positive (overexpressing) tumor tissue
* Failed prior trastuzumab (Herceptin) therapy with or without chemotherapy
* Resected stage IV disease allowed if evidence of disease
* Bidimensionally measurable or evaluable disease

  * No lesions in previously irradiated field except nonbone lesions progressive after radiotherapy
  * No pleural effusions
  * No blastic or mixed bony metastases
  * No palpable abdominal masses
* No leptomeningeal disease
* Brain metastases allowed if:

  * No concurrent use of steroids
  * At least 3 months since prior brain irradiation
  * No evidence of progression of metastases
* Hormone receptor status:

  * Not specified

PATIENT CHARACTERISTICS:

Age:

* 18 and over

Sex:

* Female

Menopausal status:

* Not specified

Performance status:

* Karnofsky 70-100%

Life expectancy:

* At least 3 months

Hematopoietic:

* Granulocyte count at least 1,500/mm\^3
* Hemoglobin at least 8.0 g/dL
* Platelet count at least 100,000/mm\^3

Hepatic:

* AST/ALT no greater than 2 times upper limit of normal (ULN)
* Bilirubin no greater than 1.5 times ULN

Renal:

* Creatinine no greater than 1.5 mg/dL

Cardiovascular:

* LVEF at least 50%

Other:

* Not pregnant
* Negative pregnancy test
* Fertile patients must use effective barrier contraception
* No other prior malignancy within the past 5 years except adequately treated carcinoma in situ of the cervix or nonmelanoma skin cancer
* No other serious medical illness
* No severe infection
* No severe malnutrition
* No prior allergic reactions to sulfonamides or celecoxib

PRIOR CONCURRENT THERAPY:

Biologic therapy:

* See Disease Characteristics
* Prior trastuzumab (Herceptin) for breast cancer allowed, either as adjuvant/neoadjuvant or for metastatic disease

Chemotherapy:

* See Disease Characteristics
* At least 4 weeks since prior chemotherapy (6 weeks for nitrosoureas or mitomycin) and recovered
* Prior cytotoxic therapy for breast cancer allowed, either as adjuvant/neoadjuvant or for metastatic disease

Endocrine therapy:

* See Disease Characteristics
* At least 3 weeks since prior hormonal therapy
* Prior exogenous hormonal therapy for stage IV disease and/or as adjuvant therapy allowed

Radiotherapy:

* See Disease Characteristics
* At least 4 weeks since prior radiotherapy and recovered
* Prior localized radiotherapy allowed if no influence on the signal measurable lesion
* Concurrent localized radiotherapy allowed if no influence on the signal measurable lesion

Surgery:

* See Disease Characteristics
* At least 3 weeks since prior major surgery and recovered
* At least 2 weeks since prior minor surgery and recovered