Combination Chemotherapy in Treating Patients With Advanced Solid Tumors

DISEASE CHARACTERISTICS:

* Histologically confirmed solid tumor not amenable to curative surgery, radiotherapy, or chemotherapy
* No brain metastases or primary brain tumors

PATIENT CHARACTERISTICS:

Age:

* 18 and over

Performance status:

* ECOG 0-2

Life expectancy:

* At least 12 weeks

Hematopoietic:

* WBC at least 3,500/mm3
* Absolute neutrophil count at least 1,500/mm3
* Platelet count at least 100,000/mm3
* Hemoglobin greater than 10 g/dL

Hepatic:

* Bilirubin no greater than 1.2 mg/dL
* AST and/or ALT less than 2.5 times upper limit of normal (ULN)
* PT no greater than ULN (anticoagulant independent)

Renal:

* Creatinine no greater than 1.5 mg/dL AND/OR
* Creatinine clearance greater than 60 mL/min

Cardiovascular:

* No New York Heart Association class III or IV heart disease
* LVEF at least 45% by MUGA or echocardiogram

Other:

* Not pregnant or nursing
* Negative pregnancy test
* Fertile patients must use effective contraception

PRIOR CONCURRENT THERAPY:

Biologic therapy:

* No prior bone marrow or peripheral blood stem cell transplantation following high dose chemotherapy
* At least 3 weeks since prior biologic therapy for cancer and recovered
* No concurrent filgrastim (G-CSF) or sargramostim (GM-CSF)

Chemotherapy:

* See Disease Characteristics
* See Biologic therapy
* No more than 1 prior chemotherapy regimen
* No prior vinca alkaloids
* Prior anthracycline allowed if total dose no greater than 300 mg/m2
* At least 3 weeks since prior chemotherapy (6 weeks for mitomycin or carmustine) and recovered

Endocrine therapy:

* At least 3 weeks since prior endocrine therapy for cancer and recovered

Radiotherapy:

* See Disease Characteristics
* No more than 1 prior radiotherapy regimen
* At least 4 weeks since prior large field radiotherapy
* At least 3 weeks since prior radiotherapy for cancer and recovered

Surgery:

* Not specified