Clinical trial · Interventional
SU5416 in Treating Patients With Malignant Mesothelioma
A Phase II Trial of SU5416 (NSC# 696819) in Patients With Malignant Mesothelioma
NCT00006014CI-TRIAL-00010520completedPhase 2ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Phase II trial to study the effectiveness of SU5416 in treating patients who have malignant mesothelioma. SU5416 may stop the growth of malignant mesothelioma by stopping blood flow to the tumor.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Malignant Mesothelioma | Malignant Mesothelioma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| semaxanib | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Arm I
- description
- Patients receive SU5416 IV over 1 hour twice weekly. Courses repeat every 4 weeks for a minimum of 2 courses in the absence of disease progression or unacceptable toxicity.
- interventionNames
- Drug: semaxanib
Primary outcomes (0)
[]Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
DISEASE CHARACTERISTICS: * Histologically or cytologically proven malignant mesothelioma (epithelial, sarcomatoid, or mixed subtype) that is not amenable to surgery or radiotherapy * Measurable disease * At least 20 mm by conventional techniques or at least 10 mm by spiral CT scan * Pleural effusions and ascites are not considered measurable lesions * Only site of measurable disease must not be located within prior radiotherapy port * Lesion must be accessible for biopsy * History of previously treated CNS metastasis allowed if: * Neurologically stable * No requirement for IV or oral steroids or IV anticonvulsants * No active or residual disease by brain CT or MRI scan * Patients with neurologic signs or symptoms suggestive of CNS metastasis must have a negative brain CT or MRI scan PATIENT CHARACTERISTICS: * Age: 18 and over * Performance status: WHO 0-2 * Life expectancy: At least 12 weeks * WBC at least 3,000/mm3 * Platelet count at least 75,000/mm3 * Bilirubin no greater than 1.5 mg/dL * SGOT and SGPT no greater than 2.5 times upper limit of normal * Creatinine no greater than 1.5 mg/dL OR creatinine clearance at least 60 mL/min * No uncompensated coronary artery disease on electrocardiogram or physical examination * No history of myocardial infarction or severe/unstable angina within the past 6 months * No severe peripheral vascular disease associated with diabetes mellitus * No deep vein or arterial thrombosis within the past 3 months * No pulmonary embolism within the past 3 months * No significant uncontrolled underlying medical or psychiatric illness * No serious active infection * Not pregnant or nursing * Negative pregnancy test * Fertile patients must use effective contraception * No active second malignancy except nonmelanomatous skin cancer or carcinoma in situ of the cervix * Patients are not considered to have active malignancy if they have completed therapy and are considered to be at less than 30% risk of relapse * No history of severe allergic or anaphylactic reactions to paclitaxel or docetaxel PRIOR CONCURRENT THERAPY: * No more than 1 prior systemic chemotherapy regimen * At least 4 weeks since prior systemic chemotherapy and recovered * Prior intrapleural cytotoxic agents (including bleomycin) allowed * No concurrent chemotherapy * At least 4 weeks since prior radiotherapy and recovered * No concurrent radiotherapy * At least 30 days since prior investigational drug and recovered * No concurrent investigational drug
References
Publications (0)
Data not yet available
No reference posted for this study.