Clinical trial · Observational
Specimen and Data Study for Ovarian Cancer Early Detection and Prevention
Northwestern Ovarian Cancer Early Detection & Prevention Program: A Specimen and Data Study
NCT00005095CI-TRIAL-00086625recruitingClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
RATIONALE: To improve strategies for detection and prevention of early-stage disease. PURPOSE: This research study is collecting specimens and data to develop better methods for early detection and prevention of ovarian cancer among the high risk population and those who have the disease.
Conditions
Conditions (9)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cervical Cancer | Malignant Cervical Neoplasm | CURATED_EXACT | 0.92 |
| Endometrial Cancer | Malignant Endometrial Neoplasm | CURATED_BROADER | 0.80 |
| Fallopian Tube Cancer | Malignant Fallopian Tube Neoplasm | ALIAS | 0.90 |
| Hereditary Breast/Ovarian Cancer (brca1, brca2) | — | UNRESOLVED | — |
| Ovarian Cancer | Malignant Ovarian Neoplasm | CURATED_EXACT | 0.92 |
| Sarcoma | Sarcoma | ONTOLOGY_EXACT | 0.98 |
| Uterine Leiomyomata | — | UNRESOLVED | — |
| Vaginal Cancer | Malignant Vaginal Neoplasm | CURATED_EXACT | 0.92 |
| Vulvar Cancer | Malignant Vulvar Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Ca-125 | Other | — | UNRESOLVED |
| screening questionnaire administration | Other | — | UNRESOLVED |
| Surgery | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- label
- High Risk for Ovarian Cancer
- description
- Women who are at increased risk of ovarian cancer based on family or personal medical history who are participating in the Northwestern Ovarian Cancer Early Detection and Prevention Program clinic.
- interventionNames
- Other: Ca-125
- Other: screening questionnaire administration
- Procedure: Surgery
- label
- Suspected or diagnosed gynecological condition
- description
- Women who are planning to undergo surgery for their gynecological condition
- label
- Control Group
- description
- Healthy subjects with no history of cancer and at general risk.
Primary outcomes (1)
- measure
- The development of ultrasound and serum tumor markers for the detection and management of ovarian cancer and other
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
DISEASE CHARACTERISTICS:
* Meets one of the following criteria:
* Considered to be at increased risk for developing ovarian cancer, as defined by one of the following:
* Has at least one first-degree relative (mother, sister, or daughter) with ovarian, primary peritoneal, or fallopian tube cancer
* Has at least two first or second degree relatives diagnosed before age 50 with either ovarian, primary peritoneal, fallopian tube, and/or pancreatic cancer who have tested positive for hereditary cancer syndrome that includes an increased risk of gynecologic cancer (e.g., BRCA1/2 or Lynch Syndrome)or have increased risk as deemed by a certified genetic counselor
* A personal or family history of a hereditary cancer syndrome that includes an increased risk of gynecologic cancer
* Increased risk as deemed by a certified genetic counselor
* Undergoing surgery for a gynecologic condition, including any of the following:
* Diagnosis of a reproductive cancer
* Benign gynecological condition (e.g., uterine leiomyomata, endometriosis, pelvic inflammatory disease, or follicular or corpus luteum ovarian cysts)
* Highly suspicious adnexal mass
* Risk-reducing prophylactic oophorectomy
PATIENT CHARACTERISTICS:
Age
* Between the ages of 18 and 80References
Publications (0)
Data not yet available
No reference posted for this study.