Flavopiridol in Treating Patients With Previously Untreated or Relapsed Mantle Cell Lymphoma

DISEASE CHARACTERISTICS:

* Histologically or cytologically confirmed mantle cell lymphoma (at initial diagnosis) nonrefractory to prior therapy or with no prior therapy

  * No documented disease progression while receiving prior chemotherapy
* CD20 and CD5 positive
* Presence of clinically and/or radiologically documented disease
* At least 1 site of disease must be bidimensionally measurable

  * Bone lesions not considered bidimensionally measurable
  * Minimum indicator lesions must be:

    * Lymph nodes at least 1.5 cm x 1.5 cm by physical exam or spiral CT scan OR
    * Other nonnodal lesions at least 1 cm x 1 cm by MRI, CT scan, or physical exam
* No known CNS involvement by lymphoma

PATIENT CHARACTERISTICS:

Age:

* 18 and over

Performance status:

* ECOG 0-2

Life expectancy:

* At least 12 weeks

Hematopoietic:

* Absolute granulocyte count at least 1,500/mm3
* Platelet count at least 75,000/mm3

Hepatic:

* Bilirubin no greater than 1.5 times upper limit or normal (ULN)
* AST no greater than 2.5 times ULN

Renal:

* Creatinine no greater than 1.5 times ULN OR
* Creatinine clearance at least 60 mL/min

Cardiovascular:

* No clinically significant cardiac symptomatology
* If history of cardiac disease, cardiac ejection fraction greater than 50%

Pulmonary:

* No clinically significant pulmonary symptomatology
* If history of symptomatic pulmonary disease:

  * FEV1, FVC, and TLC greater than 60% predicted
  * DLCO greater than 50% predicted

Other:

* Not pregnant or nursing
* Negative pregnancy test
* Fertile patients must use effective contraception
* Must be accessible for treatment and follow-up (i.e., no geographical limitations)
* No uncontrolled bacterial, fungal, or viral infection
* No other serious concurrent disease

PRIOR CONCURRENT THERAPY:

Biologic therapy:

* No prior radioactive monoclonal antibody therapy
* Prior rituximab allowed

Chemotherapy:

* See Disease Characteristics
* No more than 2 prior chemotherapy regimens allowed
* Same chemotherapy combination given for first line and second line therapy considered 2 regimens
* At least 6 weeks since prior chemotherapy
* No prior high-dose chemotherapy and stem cell transplantation
* No other concurrent cytotoxic chemotherapy

Endocrine therapy:

* No concurrent corticosteroids

Radiotherapy:

* No prior radiotherapy to greater than 25% of functioning bone marrow
* At least 4 weeks since prior radiotherapy (except low-dose, non-myelosuppressive radiotherapy) and recovered
* No concurrent radiotherapy to sole site of measurable disease

Surgery:

* At least 2 weeks since prior major surgery

Other:

* No other concurrent investigational anticancer agents