Clinical trial · Interventional
Sarcosinamide Nitrosourea in Treating Patients With Metastatic or Unresectable Solid Tumors
A Phase I Trial of Sarcosinamide Nitrosourea (SarCNU) in Patients With Solid Tumors
NCT00004079CI-TRIAL-00009240completedPhase 1ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Phase I trial to study the effectiveness of sarcosinamide nitrosourea in treating patients who have metastatic or unresectable solid tumors. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Unspecified Adult Solid Tumor, Protocol Specific | Adult Solid Neoplasm | ALIAS | 0.85 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| laboratory biomarker analysis | Other | — | UNRESOLVED |
| pharmacological study | Other | — | UNRESOLVED |
| SarCNU | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Treatment (SarCNU)
- description
- Patients receive oral sarcosinamide nitrosourea (SarCNU) on days 1, 5, and 9. Treatment continues every 28 days in the absence of disease progression or unacceptable toxicity. Cohorts of 3-6 patients receive escalating doses of SarCNU until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose preceding that at which 2 of 3 or 2 of 6 patients experience dose-limiting toxicity.
- interventionNames
- Drug: SarCNU
- Other: pharmacological study
- Other: laboratory biomarker analysis
Primary outcomes (2)
- measure
- MTD
- timeFrame
- 28 days
- measure
- Pharmacokinetics: plasma concentration-time profiles of SarCNU
- timeFrame
- Days 1 and 9 of course 1: 5, 15, 20, 30, and 45 min; 1, 2, 3, 4, and 6 hr
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Histologically documented malignancy, which is either metastatic or inoperable, for which there is no known curative or standard palliative therapy, or all standard therapeutic approaches have failed * Patients with leukemia or primary CNS malignancies are excluded; patients with metastatic disease to the CNS, who are not receiving anticonvulsants, including phenytoin, carbamazepine, phenobarbital, primidone, and felbamate, and who have reasonable expectation of surviving long enough to receive two cycles of therapy, are eligible * Life expectancy of 2 months or longer * ECOG performance status of 0-2 * Pretreatment laboratory data, obtained within 14 days of study entry, must meet the following criteria: * ANC \>= 1,500 /mm\^3 * Platelets \>= 100,000 /mm\^3 * SGOT =\< 2.5-times upper limit of normal * SGPT =\< 2.5-times upper limit of normal * Total bilirubin =\< upper limit of normal * Creatinine =\< 1.5 mg/dl * Creatinine CL \>= 60 ml/min (measured 24hr) if creatinine \> 1.5 mg/dl * DLCO \>= 80% predicted * At least 4 weeks since last receiving radiotherapy or chemotherapy and complete recovery from previous treatment related toxicity * No prior treatment with a nitrosourea or with bleomycin * No enzyme inducing anticonvulsant agents * At least 2 weeks since major surgery * Patients must not have uncontrolled serious medical or psychiatric illness * Women of childbearing potential must not be lactating or pregnant, because of the proven teratogenicity of other agents of this class; a negative pregnancy test has to be obtained within 2 weeks of entry; both fertile males and females must use adequate contraception upon entry into the study * Patients must have given signed informed consent
References
Publications (0)
Data not yet available
No reference posted for this study.