Clinical trial · Interventional
Antiviral Therapy in Treating Patients With Slowly Progressing HIV-Related Kaposi's Sarcoma
Treatment of HIV-Related Kaposi's Sarcoma and Stage I-III Slow-Proliferative Disease With Highly Active Antiretroviral Therapy (HAART)
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
RATIONALE: HIV virus is found in the lesions of most patients with Kaposi's sarcoma, and may have a role in causing Kaposi's sarcoma. Antiviral therapy acts against the HIV virus and may be an effective treatment for Kaposi's sarcoma. PURPOSE: This phase II trial is studying how well antiviral therapy works in treating patients with slowly progressing HIV-related Kaposi's sarcoma.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Sarcoma | Sarcoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| antiviral therapy | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Efficacy
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
DISEASE CHARACTERISTICS: * Stage I-III (NYU) Kaposi's sarcoma that is slowly progressive * Stable disease without progression in diameter of tumor or in number of lesions (less than 50% increase in 3 months) * No progressive disease during or after treatment for Kaposi's sarcoma * Level of viral load detectable independently from CD4+ cells * No other active AIDS pathologies PATIENT CHARACTERISTICS: Age: * 18 and over Performance status: * ECOG 0-3 Life expectancy: * Not specified Hematopoietic: * WBC greater than 1500/mm3 * Hemoglobin greater than 8 mg/dL Hepatic: * Bilirubin less than 2.5 times normal * AST and ALT less than 5 times normal * Alkaline phosphatase less than 2.5 times normal Renal: * Creatinine less than 2.5 times normal Other: * No prior malignancy except carcinoma in situ of the cervix or nonmelanomatous skin cancer * No active cytomegalovirus, herpes simplex 1 or 2, or herpes zoster infection requiring treatment PRIOR CONCURRENT THERAPY: Biologic therapy: * Not specified Chemotherapy: * Not specified Endocrine therapy: * Not specified Radiotherapy: * Not specified Surgery: * Not specified Other * No prior antiretroviral therapy OR * No prior highly active antiretroviral therapy (HAART) * No concurrent acyclovir, ganciclovir, foscarnet, or cidofovir
References
Publications (0)
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