Umbilical Cord Blood Transplantation in Treating Patients With High-Risk Hematologic Cancer

DISEASE CHARACTERISTICS:

* Histologically confirmed high risk malignancy including:

  * Acute nonlymphocytic leukemia (ANLL) after induction failure, or in first complete remission with high risk features including stem cell or biphenotypic classification (acute myeloid leukemia (AML) M0), erythroleukemia (AML M6), acute megakaryocytic leukemia (AML M7), cytogenic markers indicative of poor prognosis, or failure to achieve complete remission after standard induction therapy
  * Acute lymphocytic leukemia (ALL) or ANLL in second or subsequent remission
  * Chronic myeloid leukemia (CML) in chronic phase

    * CML with accelerated phase or blast crisis are eligible after reinduction chemotherapy converts disease to chronic phase
  * High risk ALL in first complete remission
  * Myelodysplastic syndrome with evidence of evolution to acute myeloid leukemia

    * Refractory anemia with excess blasts
    * Refractory anemia with excess blasts in transformation
  * Non-Hodgkin's lymphoma (NHL), ANLL, or ALL with recurrent disease after autologous stem cell transplantation
* Must also meet all the following conditions:

  * No HLA-ABC/DR identical related bone marrow or UCB donor
  * No 5/6 antigen matched related bone marrow or UCB donor
  * Condition precludes waiting to search and find a donor in the National Marrow Donor Registry
* Must have an available serologic matched umbilical cord blood unit in the New York Blood Center's Placental Blood Project
* No active CNS disease

PATIENT CHARACTERISTICS:

Age:

* Under 55 at time of umbilical cord blood transplantation

Performance status:

* Zubrod 0-1
* Karnofsky 80-100%

Life expectancy:

* At least 3 months

Hematopoietic:

* For patients with ALL or ANLL in remission, CML in chronic phase, or NHL without marrow involvement who elect to undergo autologous peripheral blood stem cell collection and storage:

  * WBC at least 3,000/mm\^3
  * Absolute neutrophil count at least 1,000/mm\^3
  * Platelet count at least 100,000/mm\^3

Hepatic:

* Bilirubin no greater than 2.0 mg/dL
* ALT/AST no greater than 4 times normal

Renal:

* Creatinine no greater than 2.0 mg/dL
* Creatinine clearance at least 50 mL/min

Cardiovascular:

* Normal cardiac function by echocardiogram or radionuclide scan (shortening fraction or ejection fraction at least 80% of normal value for age)

Pulmonary:

* FVC and FEV\_1 at least 60% of predicted for age
* For adults:

  * DLCO at least 60% of predicted

Other:

* HIV negative
* No active infections at time of autologous stem cell harvest or pretransplant cytoreduction
* Not pregnant or nursing
* Effective contraception required of all fertile patients

PRIOR CONCURRENT THERAPY:

Biologic therapy:

* Prior autologous stem cell transplantation allowed

Chemotherapy:

* See Disease Characteristics

Endocrine therapy:

* Not specified

Radiotherapy:

* Not specified

Surgery:

* Not specified