Clinical trial · Interventional
Chemotherapy and Radiation Therapy in Treating Patients With HIV-Related Primary Central Nervous System Lymphoma
Treatment of HIV-Related Primary Central Nervous System Lymphoma (HIV-PCNSL): A Phase II Trial With Neoadjuvant Chemotherapy (High-Dose Methotrexate (MTX) Plus High-Dose Zidovudine) and Radiotherapy
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining radiation therapy with chemotherapy may kill more tumor cells. PURPOSE: This phase II trial is studying how well giving methotrexate and zidovudine together with radiation therapy works in treating patients with HIV-related primary central nervous system lymphoma.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lymphoma | Lymphoma | ONTOLOGY_EXACT | 0.90 |
Interventions
Interventions (4)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| methotrexate | Drug | Methotrexate | ALIAS |
| neoadjuvant therapy | Procedure | — | UNRESOLVED |
| radiation therapy | Radiation | — | UNRESOLVED |
| zidovudine | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (3)
- measure
- Efficacy
- measure
- Toxicity
- measure
- Overall survival
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
DISEASE CHARACTERISTICS: * Histologically proven HIV-related non-Hodgkin's lymphoma of the CNS * No systemic lymphoma PATIENT CHARACTERISTICS: Age: * 18 and over Performance status: * WHO 0-3 Life expectancy: * Not specified Hematopoietic: * WBC at least 3000/mm\^3 * Platelet count at least 80,000/mm\^3 Hepatic: * No serious impairment of liver function Renal: * No serious impairment of renal function * Creatinine clearance at least 40 mL/min Cardiovascular: * No serious impairment of cardiac function Neurologic: * Neurological functional status 0-3 Other: * No prior or active CNS-opportunistic infections * No AIDS dementia complex * No active systemic infections PRIOR CONCURRENT THERAPY: * No prior chemotherapy or radiotherapy
References
Publications (0)
Data not yet available